Reaction Activity

Gene activity

Syntrophomonas wolfei saponavida · 1 genes

genes

KO-annotated

reactions

pathways

One carbon pool by folateMetabolism; Metabolism of cofactors and vitamins1 genes · 2 rxns

Sws_00565 K00297 metF, MTHFR R01224

5-Methyltetrahydrofolate + NADP+ <=> 5,10-Methylenetetrahydrofolate + NADPH + H+

5-methyltetrahydrofolate:NADP+ oxidoreductase

Sws_00565 K00297 metF, MTHFR R07168

5-Methyltetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + NADH + H+

5-methyltetrahydrofolate:NAD+ oxidoreductase

Other carbon fixation pathwaysMetabolism; Energy metabolism1 genes · 2 rxns

Sws_00565 K00297 metF, MTHFR R01224

5-Methyltetrahydrofolate + NADP+ <=> 5,10-Methylenetetrahydrofolate + NADPH + H+

5-methyltetrahydrofolate:NADP+ oxidoreductase

Sws_00565 K00297 metF, MTHFR R07168

5-Methyltetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + NADH + H+

5-methyltetrahydrofolate:NAD+ oxidoreductase

Antifolate resistanceHuman Diseases; Drug resistance: antineoplastic1 genes · 2 rxns

Sws_00565 K00297 metF, MTHFR R01224

5-Methyltetrahydrofolate + NADP+ <=> 5,10-Methylenetetrahydrofolate + NADPH + H+

5-methyltetrahydrofolate:NADP+ oxidoreductase

Sws_00565 K00297 metF, MTHFR R07168

5-Methyltetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + NADH + H+

5-methyltetrahydrofolate:NAD+ oxidoreductase

Metabolic pathways 1 genes

Sws_00565

Microbial metabolism in diverse environments 1 genes

Sws_00565

Carbon metabolism 1 genes

Sws_00565

show cofactors (H₂O, ATP, NAD⁺…) drag nodes · click an edge for the reaction

Locus	Product	KO	EC	Reactions
Sws_00565	methylenetetrahydrofolate reductase C-terminal domain-containing protein	K00297 metF, MTHFR	1.5.1.20	R01224,R07168