Reaction Activity

Gene activity

Syntrophomonas wolfei saponavida · 1 genes

genes

KO-annotated

reactions

pathways

Valine, leucine and isoleucine biosynthesisMetabolism; Amino acid metabolism1 genes · 3 rxns

Sws_01561 K00052 leuB, IMDH R00994

2-Oxobutanoate + CO2 + NADH + H+ <=> D-erythro-3-Methylmalate + NAD+

(2R,3S)-3-methylmalate:NAD+ oxidoreductase

Sws_01561 K00052 leuB, IMDH R04426

(2R,3S)-3-Isopropylmalate + NAD+ <=> (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+

(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase

Sws_01561 K00052 leuB, IMDH R10052

(2R,3S)-3-Isopropylmalate + NAD+ <=> 4-Methyl-2-oxopentanoate + CO2 + NADH + H+

(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase

C5-Branched dibasic acid metabolismMetabolism; Carbohydrate metabolism1 genes · 3 rxns

Sws_01561 K00052 leuB, IMDH R00994

2-Oxobutanoate + CO2 + NADH + H+ <=> D-erythro-3-Methylmalate + NAD+

(2R,3S)-3-methylmalate:NAD+ oxidoreductase

Sws_01561 K00052 leuB, IMDH R04426

(2R,3S)-3-Isopropylmalate + NAD+ <=> (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+

(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase

Sws_01561 K00052 leuB, IMDH R10052

(2R,3S)-3-Isopropylmalate + NAD+ <=> 4-Methyl-2-oxopentanoate + CO2 + NADH + H+

(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase

Metabolic pathways 1 genes

Sws_01561

Biosynthesis of secondary metabolites 1 genes

Sws_01561

2-Oxocarboxylic acid metabolism 1 genes

Sws_01561

Biosynthesis of amino acids 1 genes

Sws_01561

show cofactors (H₂O, ATP, NAD⁺…) drag nodes · click an edge for the reaction

Locus	Product	KO	EC	Reactions
Sws_01561	3-isopropylmalate dehydrogenase	K00052 leuB, IMDH	1.1.1.85	R00994,R04426,R10052