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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_CM129641.1:1,078,802–1,080,816

Syntrophomonas curvata DSM15682 · 2 genes
2
genes
2
KO-annotated
5
reactions
4
pathways

Activity by pathway — click to expand; ranked by genes involved

One carbon pool by folateMetabolism; Metabolism of cofactors and vitamins2 genes · 5 rxns
Scur_00899 K01491 folD R01220
5,10-Methylenetetrahydrofolate + NADP+ <=> 5,10-Methenyltetrahydrofolate + NADPH
5,10-methylenetetrahydrofolate:NADP+ oxidoreductase
Scur_00899 K01491 folD R01655
5,10-Methenyltetrahydrofolate + H2O <=> 10-Formyltetrahydrofolate + H+
5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)
Scur_00900 K00605 gcvT, AMT R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Scur_00900 K00605 gcvT, AMT R02300
Folinic acid <=> 5,10-Methenyltetrahydrofolate + H2O
S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming)
Scur_00900 K00605 gcvT, AMT R04125
[Protein]-S8-aminomethyldihydrolipoyllysine + Tetrahydrofolate <=> Dihydrolipoylprotein + 5,10-Methylenetetrahydrofolate + Ammonia
[protein]-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming)
Other carbon fixation pathwaysMetabolism; Energy metabolism1 genes · 2 rxns
Scur_00899 K01491 folD R01220
5,10-Methylenetetrahydrofolate + NADP+ <=> 5,10-Methenyltetrahydrofolate + NADPH
5,10-methylenetetrahydrofolate:NADP+ oxidoreductase
Scur_00899 K01491 folD R01655
5,10-Methenyltetrahydrofolate + H2O <=> 10-Formyltetrahydrofolate + H+
5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)
Glycine, serine and threonine metabolismMetabolism; Amino acid metabolism1 genes · 3 rxns
Scur_00900 K00605 gcvT, AMT R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Scur_00900 K00605 gcvT, AMT R02300
Folinic acid <=> 5,10-Methenyltetrahydrofolate + H2O
S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming)
Scur_00900 K00605 gcvT, AMT R04125
[Protein]-S8-aminomethyldihydrolipoyllysine + Tetrahydrofolate <=> Dihydrolipoylprotein + 5,10-Methylenetetrahydrofolate + Ammonia
[protein]-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming)
Glyoxylate and dicarboxylate metabolismMetabolism; Carbohydrate metabolism1 genes · 3 rxns
Scur_00900 K00605 gcvT, AMT R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Scur_00900 K00605 gcvT, AMT R02300
Folinic acid <=> 5,10-Methenyltetrahydrofolate + H2O
S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming)
Scur_00900 K00605 gcvT, AMT R04125
[Protein]-S8-aminomethyldihydrolipoyllysine + Tetrahydrofolate <=> Dihydrolipoylprotein + 5,10-Methylenetetrahydrofolate + Ammonia
[protein]-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming)

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 2 genes
Scur_00899 Scur_00900
Carbon metabolism 2 genes
Scur_00899 Scur_00900
Microbial metabolism in diverse environments 1 genes
Scur_00899
Biosynthesis of secondary metabolites 1 genes
Scur_00900
Map 01130 1 genes
Scur_00900

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Scur_00899 bifunctional 5,10-methylenetetrahydrofolate dehydrogenase/5,10-methenyltetrahydrofolate cyclohydrolase K01491 folD 1.5.1.5,3.5.4.9 R01220,R01655
Scur_00900 glycine cleavage system aminomethyltransferase GcvT K00605 gcvT, AMT 2.1.2.10 R01221,R02300,R04125
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