Reaction Activity

Operon NZ_AP042459.1:35,869–38,134

Syntrophomonas erecta sporosyntropha Sespor · 4 genes

genes

KO-annotated

reactions

pathways

Folate biosynthesisMetabolism; Metabolism of cofactors and vitamins3 genes · 4 rxns

Sesp_00037 K10026 queE R10002

6-Carboxy-5,6,7,8-tetrahydropterin <=> 7-Carboxy-7-carbaguanine + Ammonia

6-carboxy-5,6,7,8-tetrahydropterin ammonia-lyase

Sesp_00039 K06920 queC R09978

2 ATP + Ammonia + 7-Carboxy-7-carbaguanine <=> 2 AMP + 2 Diphosphate + 7-Cyano-7-carbaguanine

7-carboxy-7-carbaguanine:ammonia ligase (AMP-forming)

Sesp_00040 K01737 queD, ptpS, PTS R04286

7,8-Dihydroneopterin 3'-triphosphate <=> 6-Pyruvoyltetrahydropterin + Triphosphate

2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl) dihydropteridine triphosphate lyase

Sesp_00040 K01737 queD, ptpS, PTS R09959

7,8-Dihydroneopterin 3'-triphosphate + H2O <=> 6-Carboxy-5,6,7,8-tetrahydropterin + Acetaldehyde + Triphosphate

7,8-dihydroneopterin 3'-triphosphate acetaldehyde-lyase (6-carboxy-5,6,7,8-tetrahydropterin and triphosphate-forming)

Metabolic pathways 3 genes

Sesp_00037 Sesp_00039 Sesp_00040

show cofactors (H₂O, ATP, NAD⁺…) drag nodes · click an edge for the reaction

Locus	Product	KO	EC	Reactions
Sesp_00037	7-carboxy-7-deazaguanine synthase QueE	K10026 queE	4.3.99.3	R10002
Sesp_00038	DUF366 family protein	K09139 K09139	—	—
Sesp_00039	7-cyano-7-deazaguanine synthase QueC	K06920 queC	6.3.4.20	R09978
Sesp_00040	6-carboxytetrahydropterin synthase QueD	K01737 queD, ptpS, PTS	4.1.2.50,4.2.3.12	R04286,R09959