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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_AP042459.1:2,189,396–2,191,366

Syntrophomonas erecta sporosyntropha Sespor · 2 genes
2
genes
2
KO-annotated
12
reactions
8
pathways

Activity by pathway — click to expand; ranked by genes involved

Glycolysis / GluconeogenesisMetabolism; Carbohydrate metabolism1 genes · 4 rxns
Sesp_02058 K00161 PDHA, pdhA R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Sesp_02058 K00161 PDHA, pdhA R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Sesp_02058 K00161 PDHA, pdhA R01699
Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
Sesp_02058 K00161 PDHA, pdhA R03270
2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate
Citrate cycle (TCA cycle)Metabolism; Carbohydrate metabolism1 genes · 4 rxns
Sesp_02058 K00161 PDHA, pdhA R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Sesp_02058 K00161 PDHA, pdhA R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Sesp_02058 K00161 PDHA, pdhA R01699
Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
Sesp_02058 K00161 PDHA, pdhA R03270
2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate
Pyruvate metabolismMetabolism; Carbohydrate metabolism1 genes · 4 rxns
Sesp_02058 K00161 PDHA, pdhA R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Sesp_02058 K00161 PDHA, pdhA R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Sesp_02058 K00161 PDHA, pdhA R01699
Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
Sesp_02058 K00161 PDHA, pdhA R03270
2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate
HIF-1 signaling pathwayEnvironmental Information Processing; Signal transduction1 genes · 4 rxns
Sesp_02058 K00161 PDHA, pdhA R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Sesp_02058 K00161 PDHA, pdhA R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Sesp_02058 K00161 PDHA, pdhA R01699
Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
Sesp_02058 K00161 PDHA, pdhA R03270
2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate
Glucagon signaling pathwayOrganismal Systems; Endocrine system1 genes · 4 rxns
Sesp_02058 K00161 PDHA, pdhA R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Sesp_02058 K00161 PDHA, pdhA R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Sesp_02058 K00161 PDHA, pdhA R01699
Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
Sesp_02058 K00161 PDHA, pdhA R03270
2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate
Central carbon metabolism in cancerHuman Diseases; Cancer: overview1 genes · 4 rxns
Sesp_02058 K00161 PDHA, pdhA R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Sesp_02058 K00161 PDHA, pdhA R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Sesp_02058 K00161 PDHA, pdhA R01699
Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
Sesp_02058 K00161 PDHA, pdhA R03270
2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate
Valine, leucine and isoleucine degradationMetabolism; Amino acid metabolism1 genes · 8 rxns
Sesp_02059 K11381 bkdA R07599
3-Methyl-2-oxobutanoic acid + Thiamin diphosphate <=> 2-Methyl-1-hydroxypropyl-ThPP + CO2
Sesp_02059 K11381 bkdA R07600
2-Methyl-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + Thiamin diphosphate
Sesp_02059 K11381 bkdA R07601
4-Methyl-2-oxopentanoate + Thiamin diphosphate <=> 3-Methyl-1-hydroxybutyl-ThPP + CO2
Sesp_02059 K11381 bkdA R07602
3-Methyl-1-hydroxybutyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine + Thiamin diphosphate
Sesp_02059 K11381 bkdA R07603
(S)-3-Methyl-2-oxopentanoic acid + Thiamin diphosphate <=> 2-Methyl-1-hydroxybutyl-ThPP + CO2
Sesp_02059 K11381 bkdA R07604
2-Methyl-1-hydroxybutyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + Thiamin diphosphate
Sesp_02059 K11381 bkdA R10996
2-Oxobutanoate + Thiamin diphosphate <=> 2-(alpha-Hydroxypropyl)thiamine diphosphate + CO2
Sesp_02059 K11381 bkdA R10997
2-(alpha-Hydroxypropyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> Enzyme N6-(S-propyldihydrolipoyl)lysine + Thiamin diphosphate
Propanoate metabolismMetabolism; Carbohydrate metabolism1 genes · 8 rxns
Sesp_02059 K11381 bkdA R07599
3-Methyl-2-oxobutanoic acid + Thiamin diphosphate <=> 2-Methyl-1-hydroxypropyl-ThPP + CO2
Sesp_02059 K11381 bkdA R07600
2-Methyl-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + Thiamin diphosphate
Sesp_02059 K11381 bkdA R07601
4-Methyl-2-oxopentanoate + Thiamin diphosphate <=> 3-Methyl-1-hydroxybutyl-ThPP + CO2
Sesp_02059 K11381 bkdA R07602
3-Methyl-1-hydroxybutyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine + Thiamin diphosphate
Sesp_02059 K11381 bkdA R07603
(S)-3-Methyl-2-oxopentanoic acid + Thiamin diphosphate <=> 2-Methyl-1-hydroxybutyl-ThPP + CO2
Sesp_02059 K11381 bkdA R07604
2-Methyl-1-hydroxybutyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + Thiamin diphosphate
Sesp_02059 K11381 bkdA R10996
2-Oxobutanoate + Thiamin diphosphate <=> 2-(alpha-Hydroxypropyl)thiamine diphosphate + CO2
Sesp_02059 K11381 bkdA R10997
2-(alpha-Hydroxypropyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> Enzyme N6-(S-propyldihydrolipoyl)lysine + Thiamin diphosphate

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 2 genes
Sesp_02058 Sesp_02059
Biosynthesis of secondary metabolites 2 genes
Sesp_02058 Sesp_02059
Map 01130 2 genes
Sesp_02058 Sesp_02059
Microbial metabolism in diverse environments 1 genes
Sesp_02058
Carbon metabolism 1 genes
Sesp_02058

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Sesp_02058 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha K00161 PDHA, pdhA; K21416 acoA 1.2.4.1 R00014,R00209,R01699,R03270
Sesp_02059 alpha-ketoacid dehydrogenase subunit beta K11381 bkdA; K21417 acoB 1.2.4.4 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997
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