Small Microbes Pathway Profiler

Domain Counts
Profiler Search and BLAST
CAZy ▾
CAZyme Browser CAzy - DBCAN (original) CAZyme protein counts Proteome Coverage Summary
Search ▾
Text search Domain display search
Pathways ▾
Nitrogen Fixation CANT-Hyd
UMAP
◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_BBCE01000006.1:26,748–31,977

Syntrophomonas palmitatica JCM14374 Spalm · 4 genes
4
genes
4
KO-annotated
16
reactions
4
pathways

Activity by pathway — click to expand; ranked by genes involved

Valine, leucine and isoleucine biosynthesisMetabolism; Amino acid metabolism4 genes · 23 rxns
Spalm_00889 K01687 ilvD R01209
2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O
2,3-dihydroxy-3-methylbutanoate hydro-lyase
Spalm_00889 K01687 ilvD R04441
(R)-2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O
(R)-2,3-dihydroxy-3-methylbutanoate hydro-lyase
Spalm_00889 K01687 ilvD R05070
(R)-2,3-Dihydroxy-3-methylpentanoate <=> (S)-3-Methyl-2-oxopentanoic acid + H2O
(R)-2,3-dihydroxy-3-methylpentanoate hydro-lyase
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Spalm_00892 K00053 ilvC R03051
2-Acetolactate + NADPH + H+ <=> 2,3-Dihydroxy-3-methylbutanoate + NADP+
2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
Spalm_00892 K00053 ilvC R04439
(R)-2,3-Dihydroxy-3-methylbutanoate + NADP+ <=> (S)-2-Acetolactate + NADPH + H+
(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
Spalm_00892 K00053 ilvC R04440
(R)-2,3-Dihydroxy-3-methylbutanoate + NADP+ <=> 3-Hydroxy-3-methyl-2-oxobutanoic acid + NADPH + H+
(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
Spalm_00892 K00053 ilvC R05068
(R)-2,3-Dihydroxy-3-methylpentanoate + NADP+ <=> (R)-3-Hydroxy-3-methyl-2-oxopentanoate + NADPH + H+
(R)-2,3-dihydroxy-3-methylpentanoate:NADP+ oxidoreductase (isomerizing)
Spalm_00892 K00053 ilvC R05069
(S)-2-Aceto-2-hydroxybutanoate <=> (R)-3-Hydroxy-3-methyl-2-oxopentanoate
(S)-2-aceto-2-hydroxybutanoate:NADP+ oxidoreductase (isomerizing)
Spalm_00892 K00053 ilvC R05071
(S)-2-Acetolactate <=> 3-Hydroxy-3-methyl-2-oxobutanoic acid
(S)-2-acetolactate methylmutase
Pantothenate and CoA biosynthesisMetabolism; Metabolism of cofactors and vitamins4 genes · 23 rxns
Spalm_00889 K01687 ilvD R01209
2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O
2,3-dihydroxy-3-methylbutanoate hydro-lyase
Spalm_00889 K01687 ilvD R04441
(R)-2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O
(R)-2,3-dihydroxy-3-methylbutanoate hydro-lyase
Spalm_00889 K01687 ilvD R05070
(R)-2,3-Dihydroxy-3-methylpentanoate <=> (S)-3-Methyl-2-oxopentanoic acid + H2O
(R)-2,3-dihydroxy-3-methylpentanoate hydro-lyase
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Spalm_00892 K00053 ilvC R03051
2-Acetolactate + NADPH + H+ <=> 2,3-Dihydroxy-3-methylbutanoate + NADP+
2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
Spalm_00892 K00053 ilvC R04439
(R)-2,3-Dihydroxy-3-methylbutanoate + NADP+ <=> (S)-2-Acetolactate + NADPH + H+
(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
Spalm_00892 K00053 ilvC R04440
(R)-2,3-Dihydroxy-3-methylbutanoate + NADP+ <=> 3-Hydroxy-3-methyl-2-oxobutanoic acid + NADPH + H+
(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)
Spalm_00892 K00053 ilvC R05068
(R)-2,3-Dihydroxy-3-methylpentanoate + NADP+ <=> (R)-3-Hydroxy-3-methyl-2-oxopentanoate + NADPH + H+
(R)-2,3-dihydroxy-3-methylpentanoate:NADP+ oxidoreductase (isomerizing)
Spalm_00892 K00053 ilvC R05069
(S)-2-Aceto-2-hydroxybutanoate <=> (R)-3-Hydroxy-3-methyl-2-oxopentanoate
(S)-2-aceto-2-hydroxybutanoate:NADP+ oxidoreductase (isomerizing)
Spalm_00892 K00053 ilvC R05071
(S)-2-Acetolactate <=> 3-Hydroxy-3-methyl-2-oxobutanoic acid
(S)-2-acetolactate methylmutase
Butanoate metabolismMetabolism; Carbohydrate metabolism2 genes · 14 rxns
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
C5-Branched dibasic acid metabolismMetabolism; Carbohydrate metabolism2 genes · 14 rxns
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Spalm_00890 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Spalm_00891 K01653 E2.2.1.6S, ilvH, ilvN R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 4 genes
Spalm_00889 Spalm_00890 Spalm_00891 Spalm_00892
Biosynthesis of secondary metabolites 4 genes
Spalm_00889 Spalm_00890 Spalm_00891 Spalm_00892
Map 01130 4 genes
Spalm_00889 Spalm_00890 Spalm_00891 Spalm_00892
2-Oxocarboxylic acid metabolism 4 genes
Spalm_00889 Spalm_00890 Spalm_00891 Spalm_00892
Biosynthesis of amino acids 4 genes
Spalm_00889 Spalm_00890 Spalm_00891 Spalm_00892

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Spalm_00889 dihydroxy-acid dehydratase K01687 ilvD 4.2.1.9 R01209,R04441,R05070
Spalm_00890 biosynthetic-type acetolactate synthase large subunit K01652 E2.2.1.6L, ilvB, ilvG, ilvI 2.2.1.6 R00006,R00014,R00226,R03050,R04672,R04673,R08648
Spalm_00891 acetolactate synthase small subunit K01653 E2.2.1.6S, ilvH, ilvN 2.2.1.6 R00006,R00014,R00226,R03050,R04672,R04673,R08648
Spalm_00892 ketol-acid reductoisomerase K00053 ilvC 1.1.1.86 R03051,R04439,R04440,R05068,R05069,R05071
↑ Top




v1.00 @copyright 2026 UCLA