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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_BBCE01000006.1:35,003–38,402

Syntrophomonas palmitatica JCM14374 Spalm · 4 genes
4
genes
3
KO-annotated
9
reactions
3
pathways

Activity by pathway — click to expand; ranked by genes involved

Valine, leucine and isoleucine biosynthesisMetabolism; Amino acid metabolism3 genes · 9 rxns
Spalm_00893 K01704 leuD, IPMI-S R03896
(R)-2-Methylmalate <=> 2-Methylmaleate + H2O
(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)
Spalm_00893 K01704 leuD, IPMI-S R03898
2-Methylmaleate + H2O <=> D-erythro-3-Methylmalate
2-methylmaleate hydratase; D-erythro-3-methylmalate hydro-lyase (2-methylmaleate-forming)
Spalm_00893 K01704 leuD, IPMI-S R03968
alpha-Isopropylmalate <=> 2-Isopropylmaleate + H2O
2-isopropylmalate hydro-lyase
Spalm_00893 K01704 leuD, IPMI-S R04001
(2R,3S)-3-Isopropylmalate <=> 2-Isopropylmaleate + H2O
3-isopropylmalate hydro-lyase
Spalm_00893 K01704 leuD, IPMI-S R10170
(2R,3S)-3-Isopropylmalate <=> alpha-Isopropylmalate
(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
Spalm_00894 K00052 leuB, IMDH R00994
2-Oxobutanoate + CO2 + NADH + H+ <=> D-erythro-3-Methylmalate + NAD+
(2R,3S)-3-methylmalate:NAD+ oxidoreductase
Spalm_00894 K00052 leuB, IMDH R04426
(2R,3S)-3-Isopropylmalate + NAD+ <=> (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+
(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
Spalm_00894 K00052 leuB, IMDH R10052
(2R,3S)-3-Isopropylmalate + NAD+ <=> 4-Methyl-2-oxopentanoate + CO2 + NADH + H+
(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
Spalm_00895 K01649 leuA, IMS R01213
alpha-Isopropylmalate + CoA <=> Acetyl-CoA + 3-Methyl-2-oxobutanoic acid + H2O
acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming); 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)
C5-Branched dibasic acid metabolismMetabolism; Carbohydrate metabolism2 genes · 8 rxns
Spalm_00893 K01704 leuD, IPMI-S R03896
(R)-2-Methylmalate <=> 2-Methylmaleate + H2O
(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)
Spalm_00893 K01704 leuD, IPMI-S R03898
2-Methylmaleate + H2O <=> D-erythro-3-Methylmalate
2-methylmaleate hydratase; D-erythro-3-methylmalate hydro-lyase (2-methylmaleate-forming)
Spalm_00893 K01704 leuD, IPMI-S R03968
alpha-Isopropylmalate <=> 2-Isopropylmaleate + H2O
2-isopropylmalate hydro-lyase
Spalm_00893 K01704 leuD, IPMI-S R04001
(2R,3S)-3-Isopropylmalate <=> 2-Isopropylmaleate + H2O
3-isopropylmalate hydro-lyase
Spalm_00893 K01704 leuD, IPMI-S R10170
(2R,3S)-3-Isopropylmalate <=> alpha-Isopropylmalate
(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
Spalm_00894 K00052 leuB, IMDH R00994
2-Oxobutanoate + CO2 + NADH + H+ <=> D-erythro-3-Methylmalate + NAD+
(2R,3S)-3-methylmalate:NAD+ oxidoreductase
Spalm_00894 K00052 leuB, IMDH R04426
(2R,3S)-3-Isopropylmalate + NAD+ <=> (2S)-2-Isopropyl-3-oxosuccinate + NADH + H+
(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
Spalm_00894 K00052 leuB, IMDH R10052
(2R,3S)-3-Isopropylmalate + NAD+ <=> 4-Methyl-2-oxopentanoate + CO2 + NADH + H+
(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase
Pyruvate metabolismMetabolism; Carbohydrate metabolism1 genes · 1 rxns
Spalm_00895 K01649 leuA, IMS R01213
alpha-Isopropylmalate + CoA <=> Acetyl-CoA + 3-Methyl-2-oxobutanoic acid + H2O
acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming); 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 3 genes
Spalm_00893 Spalm_00894 Spalm_00895
Biosynthesis of secondary metabolites 3 genes
Spalm_00893 Spalm_00894 Spalm_00895
2-Oxocarboxylic acid metabolism 3 genes
Spalm_00893 Spalm_00894 Spalm_00895
Biosynthesis of amino acids 3 genes
Spalm_00893 Spalm_00894 Spalm_00895

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Spalm_00893 3-isopropylmalate dehydratase small subunit K01704 leuD, IPMI-S 4.2.1.33,4.2.1.35 R03896,R03898,R03968,R04001,R10170
Spalm_00894 3-isopropylmalate dehydrogenase K00052 leuB, IMDH 1.1.1.85 R00994,R04426,R10052
Spalm_00895 citramalate synthase K01649 leuA, IMS 2.3.3.13 R01213
Spalm_00896 alpha-isopropylmalate synthase regulatory domain-containing protein — — —
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