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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_BBCE01000001.1:154,632–157,875

Syntrophomonas palmitatica JCM14374 Spalm · 3 genes
3
genes
3
KO-annotated
5
reactions
3
pathways

Activity by pathway — click to expand; ranked by genes involved

Purine metabolismMetabolism; Nucleotide metabolism3 genes · 5 rxns
Spalm_00159 K00602 purH R01127
IMP + H2O <=> 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
IMP 1,2-hydrolase (decyclizing)
Spalm_00159 K00602 purH R04560
10-Formyltetrahydrofolate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide <=> Tetrahydrofolate + 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase
Spalm_00160 K11175 purN R04325
10-Formyltetrahydrofolate + 5'-Phosphoribosylglycinamide <=> Tetrahydrofolate + 5'-Phosphoribosyl-N-formylglycinamide
10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase
Spalm_00160 K11175 purN R04326
5'-Phosphoribosylglycinamide + 5,10-Methenyltetrahydrofolate + H2O <=> 5'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolate
Spalm_00161 K01933 purM R04208
ATP + 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine <=> ADP + Orthophosphate + Aminoimidazole ribotide
2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)
One carbon pool by folateMetabolism; Metabolism of cofactors and vitamins2 genes · 4 rxns
Spalm_00159 K00602 purH R01127
IMP + H2O <=> 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
IMP 1,2-hydrolase (decyclizing)
Spalm_00159 K00602 purH R04560
10-Formyltetrahydrofolate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide <=> Tetrahydrofolate + 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase
Spalm_00160 K11175 purN R04325
10-Formyltetrahydrofolate + 5'-Phosphoribosylglycinamide <=> Tetrahydrofolate + 5'-Phosphoribosyl-N-formylglycinamide
10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase
Spalm_00160 K11175 purN R04326
5'-Phosphoribosylglycinamide + 5,10-Methenyltetrahydrofolate + H2O <=> 5'-Phosphoribosyl-N-formylglycinamide + Tetrahydrofolate
Antifolate resistanceHuman Diseases; Drug resistance: antineoplastic1 genes · 2 rxns
Spalm_00159 K00602 purH R01127
IMP + H2O <=> 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
IMP 1,2-hydrolase (decyclizing)
Spalm_00159 K00602 purH R04560
10-Formyltetrahydrofolate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide <=> Tetrahydrofolate + 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 3 genes
Spalm_00159 Spalm_00160 Spalm_00161
Biosynthesis of secondary metabolites 3 genes
Spalm_00159 Spalm_00160 Spalm_00161
Map 01130 3 genes
Spalm_00159 Spalm_00160 Spalm_00161

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Spalm_00159 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase K00602 purH 2.1.2.3,3.5.4.10 R01127,R04560
Spalm_00160 phosphoribosylglycinamide formyltransferase K11175 purN 2.1.2.2 R04325,R04326
Spalm_00161 phosphoribosylformylglycinamidine cyclo-ligase K01933 purM 6.3.3.1 R04208
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