Reaction Activity

◀ domain architecture · operons · ❔ guide

Operon NZ_CGIH01000001.1:778–6,862

Syntrophomonas zehnderi OL-4 Szehn · 5 genes

genes

KO-annotated

reactions

pathways

Activity by pathway — click to expand; ranked by genes involved

Fatty acid degradationMetabolism; Lipid metabolism3 genes · 28 rxns

Szeh_00002 K01897 ACSL, fadD R01280

ATP + Hexadecanoic acid + CoA <=> AMP + Palmitoyl-CoA + Diphosphate

palmitate:CoA ligase (AMP-forming)

Szeh_00003 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Szeh_00003 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Szeh_00003 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Szeh_00005 K00249 ACADM, acd R01175

Butanoyl-CoA + FAD <=> FADH2 + Crotonoyl-CoA

butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R01279

Palmitoyl-CoA + FAD <=> trans-Hexadec-2-enoyl-CoA + FADH2

palmitoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R02661

2-Methylpropanoyl-CoA + Acceptor <=> 2-Methylprop-2-enoyl-CoA + Reduced acceptor

2-methylpropanoyl-CoA:(acceptor) 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03172

(S)-2-Methylbutanoyl-CoA + Acceptor <=> 2-Methylbut-2-enoyl-CoA + Reduced acceptor

(S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03777

Octanoyl-CoA + FAD <=> trans-Oct-2-enoyl-CoA + FADH2

octanoyl-CoA:electron-transfer flavoprotein 2-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03857

Lauroyl-CoA + FAD <=> 2-trans-Dodecenoyl-CoA + FADH2

lauroyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03990

Tetradecanoyl-CoA + FAD <=> trans-Tetradec-2-enoyl-CoA + FADH2

tetradecanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04095

3-Methylbutanoyl-CoA + FAD <=> 3-Methylcrotonyl-CoA + FADH2

3-methylbutanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04432

Electron-transferring flavoprotein + Propanoyl-CoA <=> Reduced electron-transferring flavoprotein + Propenoyl-CoA

propanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04751

Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2

hexanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04754

Decanoyl-CoA + FAD <=> trans-Dec-2-enoyl-CoA + FADH2

decanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

beta-Alanine metabolismMetabolism; Metabolism of other amino acids2 genes · 27 rxns

Szeh_00003 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Szeh_00003 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Szeh_00003 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Szeh_00005 K00249 ACADM, acd R01175

Butanoyl-CoA + FAD <=> FADH2 + Crotonoyl-CoA

butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R01279

Palmitoyl-CoA + FAD <=> trans-Hexadec-2-enoyl-CoA + FADH2

palmitoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R02661

2-Methylpropanoyl-CoA + Acceptor <=> 2-Methylprop-2-enoyl-CoA + Reduced acceptor

2-methylpropanoyl-CoA:(acceptor) 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03172

(S)-2-Methylbutanoyl-CoA + Acceptor <=> 2-Methylbut-2-enoyl-CoA + Reduced acceptor

(S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03777

Octanoyl-CoA + FAD <=> trans-Oct-2-enoyl-CoA + FADH2

octanoyl-CoA:electron-transfer flavoprotein 2-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03857

Lauroyl-CoA + FAD <=> 2-trans-Dodecenoyl-CoA + FADH2

lauroyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03990

Tetradecanoyl-CoA + FAD <=> trans-Tetradec-2-enoyl-CoA + FADH2

tetradecanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04095

3-Methylbutanoyl-CoA + FAD <=> 3-Methylcrotonyl-CoA + FADH2

3-methylbutanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04432

Electron-transferring flavoprotein + Propanoyl-CoA <=> Reduced electron-transferring flavoprotein + Propenoyl-CoA

propanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04751

Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2

hexanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04754

Decanoyl-CoA + FAD <=> trans-Dec-2-enoyl-CoA + FADH2

decanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

PPAR signaling pathwayOrganismal Systems; Endocrine system2 genes · 12 rxns

Szeh_00002 K01897 ACSL, fadD R01280

ATP + Hexadecanoic acid + CoA <=> AMP + Palmitoyl-CoA + Diphosphate

palmitate:CoA ligase (AMP-forming)

Szeh_00005 K00249 ACADM, acd R01175

Butanoyl-CoA + FAD <=> FADH2 + Crotonoyl-CoA

butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R01279

Palmitoyl-CoA + FAD <=> trans-Hexadec-2-enoyl-CoA + FADH2

palmitoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R02661

2-Methylpropanoyl-CoA + Acceptor <=> 2-Methylprop-2-enoyl-CoA + Reduced acceptor

2-methylpropanoyl-CoA:(acceptor) 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03172

(S)-2-Methylbutanoyl-CoA + Acceptor <=> 2-Methylbut-2-enoyl-CoA + Reduced acceptor

(S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03777

Octanoyl-CoA + FAD <=> trans-Oct-2-enoyl-CoA + FADH2

octanoyl-CoA:electron-transfer flavoprotein 2-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03857

Lauroyl-CoA + FAD <=> 2-trans-Dodecenoyl-CoA + FADH2

lauroyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03990

Tetradecanoyl-CoA + FAD <=> trans-Tetradec-2-enoyl-CoA + FADH2

tetradecanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04095

3-Methylbutanoyl-CoA + FAD <=> 3-Methylcrotonyl-CoA + FADH2

3-methylbutanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04432

Electron-transferring flavoprotein + Propanoyl-CoA <=> Reduced electron-transferring flavoprotein + Propenoyl-CoA

propanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04751

Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2

hexanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04754

Decanoyl-CoA + FAD <=> trans-Dec-2-enoyl-CoA + FADH2

decanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Valine, leucine and isoleucine degradationMetabolism; Amino acid metabolism2 genes · 27 rxns

Szeh_00003 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Szeh_00003 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Szeh_00003 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Szeh_00005 K00249 ACADM, acd R01175

Butanoyl-CoA + FAD <=> FADH2 + Crotonoyl-CoA

butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R01279

Palmitoyl-CoA + FAD <=> trans-Hexadec-2-enoyl-CoA + FADH2

palmitoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R02661

2-Methylpropanoyl-CoA + Acceptor <=> 2-Methylprop-2-enoyl-CoA + Reduced acceptor

2-methylpropanoyl-CoA:(acceptor) 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03172

(S)-2-Methylbutanoyl-CoA + Acceptor <=> 2-Methylbut-2-enoyl-CoA + Reduced acceptor

(S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03777

Octanoyl-CoA + FAD <=> trans-Oct-2-enoyl-CoA + FADH2

octanoyl-CoA:electron-transfer flavoprotein 2-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03857

Lauroyl-CoA + FAD <=> 2-trans-Dodecenoyl-CoA + FADH2

lauroyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03990

Tetradecanoyl-CoA + FAD <=> trans-Tetradec-2-enoyl-CoA + FADH2

tetradecanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04095

3-Methylbutanoyl-CoA + FAD <=> 3-Methylcrotonyl-CoA + FADH2

3-methylbutanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04432

Electron-transferring flavoprotein + Propanoyl-CoA <=> Reduced electron-transferring flavoprotein + Propenoyl-CoA

propanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04751

Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2

hexanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04754

Decanoyl-CoA + FAD <=> trans-Dec-2-enoyl-CoA + FADH2

decanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Propanoate metabolismMetabolism; Carbohydrate metabolism2 genes · 27 rxns

Szeh_00003 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Szeh_00003 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Szeh_00003 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Szeh_00005 K00249 ACADM, acd R01175

Butanoyl-CoA + FAD <=> FADH2 + Crotonoyl-CoA

butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R01279

Palmitoyl-CoA + FAD <=> trans-Hexadec-2-enoyl-CoA + FADH2

palmitoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R02661

2-Methylpropanoyl-CoA + Acceptor <=> 2-Methylprop-2-enoyl-CoA + Reduced acceptor

2-methylpropanoyl-CoA:(acceptor) 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03172

(S)-2-Methylbutanoyl-CoA + Acceptor <=> 2-Methylbut-2-enoyl-CoA + Reduced acceptor

(S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03777

Octanoyl-CoA + FAD <=> trans-Oct-2-enoyl-CoA + FADH2

octanoyl-CoA:electron-transfer flavoprotein 2-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03857

Lauroyl-CoA + FAD <=> 2-trans-Dodecenoyl-CoA + FADH2

lauroyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R03990

Tetradecanoyl-CoA + FAD <=> trans-Tetradec-2-enoyl-CoA + FADH2

tetradecanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04095

3-Methylbutanoyl-CoA + FAD <=> 3-Methylcrotonyl-CoA + FADH2

3-methylbutanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04432

Electron-transferring flavoprotein + Propanoyl-CoA <=> Reduced electron-transferring flavoprotein + Propenoyl-CoA

propanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04751

Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2

hexanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Szeh_00005 K00249 ACADM, acd R04754

Decanoyl-CoA + FAD <=> trans-Dec-2-enoyl-CoA + FADH2

decanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Caprolactam degradationMetabolism; Xenobiotics biodegradation and metabolism1 genes · 16 rxns

Szeh_00003 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Szeh_00003 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Szeh_00003 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Limonene degradationMetabolism; Metabolism of terpenoids and polyketides1 genes · 16 rxns

Szeh_00003 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Szeh_00003 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Szeh_00003 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Butanoate metabolismMetabolism; Carbohydrate metabolism1 genes · 16 rxns

Szeh_00003 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Szeh_00003 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Szeh_00003 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Aminobenzoate degradationMetabolism; Xenobiotics biodegradation and metabolism1 genes · 16 rxns

Szeh_00003 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Szeh_00003 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Szeh_00003 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Fatty acid biosynthesisMetabolism; Lipid metabolism1 genes · 1 rxns

Szeh_00002 K01897 ACSL, fadD R01280

ATP + Hexadecanoic acid + CoA <=> AMP + Palmitoyl-CoA + Diphosphate

palmitate:CoA ligase (AMP-forming)

Tryptophan metabolismMetabolism; Amino acid metabolism1 genes · 16 rxns

Szeh_00003 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Szeh_00003 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Szeh_00003 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Benzoate degradationMetabolism; Xenobiotics biodegradation and metabolism1 genes · 16 rxns

Szeh_00003 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Szeh_00003 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Szeh_00003 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Lysine degradationMetabolism; Amino acid metabolism1 genes · 16 rxns

Szeh_00003 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Szeh_00003 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Szeh_00003 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Pathway 002811 genes · 16 rxns

Szeh_00003 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Szeh_00003 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Szeh_00003 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Adipocytokine signaling pathwayOrganismal Systems; Endocrine system1 genes · 1 rxns

Szeh_00002 K01897 ACSL, fadD R01280

ATP + Hexadecanoic acid + CoA <=> AMP + Palmitoyl-CoA + Diphosphate

palmitate:CoA ligase (AMP-forming)

ThermogenesisOrganismal Systems; Environmental adaptation1 genes · 1 rxns

Szeh_00002 K01897 ACSL, fadD R01280

ATP + Hexadecanoic acid + CoA <=> AMP + Palmitoyl-CoA + Diphosphate

palmitate:CoA ligase (AMP-forming)

FerroptosisCellular Processes; Cell growth and death1 genes · 1 rxns

Szeh_00002 K01897 ACSL, fadD R01280

ATP + Hexadecanoic acid + CoA <=> AMP + Palmitoyl-CoA + Diphosphate

palmitate:CoA ligase (AMP-forming)

PeroxisomeCellular Processes; Transport and catabolism1 genes · 1 rxns

Szeh_00002 K01897 ACSL, fadD R01280

ATP + Hexadecanoic acid + CoA <=> AMP + Palmitoyl-CoA + Diphosphate

palmitate:CoA ligase (AMP-forming)

Quorum sensingCellular Processes; Cellular community - prokaryotes1 genes · 1 rxns

Szeh_00002 K01897 ACSL, fadD R01280

ATP + Hexadecanoic acid + CoA <=> AMP + Palmitoyl-CoA + Diphosphate

palmitate:CoA ligase (AMP-forming)

Phenylalanine metabolismMetabolism; Amino acid metabolism1 genes · 16 rxns

Szeh_00003 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Szeh_00003 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Szeh_00003 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Szeh_00003 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 3 genes

Szeh_00002 Szeh_00003 Szeh_00005

Fatty acid metabolism 3 genes

Szeh_00002 Szeh_00003 Szeh_00005

Carbon metabolism 2 genes

Szeh_00003 Szeh_00005

Map 01130 2 genes

Szeh_00003 Szeh_00005

Biosynthesis of secondary metabolites 2 genes

Szeh_00003 Szeh_00005

Microbial metabolism in diverse environments 1 genes

Szeh_00003

Reaction network — compounds linked by the reactions these genes catalyse

show cofactors (H₂O, ATP, NAD⁺…) drag nodes · click an edge for the reaction

Genes

Locus	Product	KO	EC	Reactions
Szeh_00002	AMP-dependent synthetase/ligase	K01897 ACSL, fadD	6.2.1.3	R01280
Szeh_00003	enoyl-CoA hydratase/isomerase family protein	K01692 paaF, echA; K01715 crt	4.2.1.17	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093
Szeh_00004	TetR/AcrR family transcriptional regulator	—	—	—
Szeh_00005	acyl-CoA dehydrogenase family protein	K00249 ACADM, acd	1.3.8.7	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754
Szeh_00006	enoyl-CoA hydratase/isomerase family protein	—	—	—

Small Microbes Pathway Profiler

Operon NZ_CGIH01000001.1:778–6,862

Activity by pathway — click to expand; ranked by genes involved

Overview / global maps (every metabolic gene maps here)

Reaction network — compounds linked by the reactions these genes catalyse

Genes