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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_CGIH01000038.1:36,587–43,189

Syntrophomonas zehnderi OL-4 Szehn · 6 genes
6
genes
6
KO-annotated
7
reactions
1
pathways

Activity by pathway — click to expand; ranked by genes involved

Porphyrin metabolismMetabolism; Metabolism of cofactors and vitamins5 genes · 9 rxns
Szeh_02125 K01698 hemB, ALAD R00036
2 5-Aminolevulinate <=> Porphobilinogen + 2 H2O
5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)
Szeh_02127 K02302 cysG R02864
Siroheme + 2 H+ <=> Fe2+ + Sirohydrochlorin
S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase
Szeh_02127 K02302 cysG R03165
Hydroxymethylbilane <=> Uroporphyrinogen III + H2O
hydroxymethylbilane hydro-lyase(cyclizing)
Szeh_02127 K02302 cysG R03194
2 S-Adenosyl-L-methionine + Uroporphyrinogen III <=> 2 S-Adenosyl-L-homocysteine + Precorrin 2
S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase
Szeh_02127 K02302 cysG R03947
Precorrin 2 + NAD+ <=> Sirohydrochlorin + NADH + H+
S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase
Szeh_02128 K01749 hemC, HMBS R00084
4 Porphobilinogen + H2O <=> Hydroxymethylbilane + 4 Ammonia
porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing); porphobilinogen ammonia-lyase (polymerizing)
Szeh_02129 K02492 hemA R04109
L-Glutamyl-tRNA(Glu) + NADPH + H+ <=> (S)-4-Amino-5-oxopentanoate + tRNA(Glu) + NADP+
L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNA(Glu)-forming)
Szeh_02130 K02304 MET8 R02864
Siroheme + 2 H+ <=> Fe2+ + Sirohydrochlorin
S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase
Szeh_02130 K02304 MET8 R03947
Precorrin 2 + NAD+ <=> Sirohydrochlorin + NADH + H+
S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 5 genes
Szeh_02125 Szeh_02127 Szeh_02128 Szeh_02129 Szeh_02130
Biosynthesis of secondary metabolites 5 genes
Szeh_02125 Szeh_02127 Szeh_02128 Szeh_02129 Szeh_02130
Microbial metabolism in diverse environments 5 genes
Szeh_02125 Szeh_02127 Szeh_02128 Szeh_02129 Szeh_02130

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Szeh_02125 porphobilinogen synthase K01698 hemB, ALAD 4.2.1.24 R00036
Szeh_02126 radical SAM/SPASM domain-containing protein K22226 ahbC — —
Szeh_02127 uroporphyrinogen-III C-methyltransferase K02302 cysG; K02303 cobA; K13542 cobA-hemD 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 R02864,R03165,R03194,R03947
Szeh_02128 hydroxymethylbilane synthase K01749 hemC, HMBS 2.5.1.61 R00084
Szeh_02129 glutamyl-tRNA reductase K02492 hemA 1.2.1.70 R04109
Szeh_02130 precorrin-2 dehydrogenase/sirohydrochlorin ferrochelatase family protein K02304 MET8 1.3.1.76,4.99.1.4 R02864,R03947
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