Reaction Activity

Operon NZ_CGIH01000005.1:50,483–53,152

Syntrophomonas zehnderi OL-4 Szehn · 4 genes

genes

KO-annotated

reactions

pathways

Folate biosynthesisMetabolism; Metabolism of cofactors and vitamins3 genes · 6 rxns

Szeh_00455 K00796 folP R03066

6-(Hydroxymethyl)-7,8-dihydropterin + 4-Aminobenzoate <=> Dihydropteroate + H2O

6-(hydroxymethyl)-7,8-dihydropterin:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase

Szeh_00455 K00796 folP R03067

6-Hydroxymethyl-7,8-dihydropterin diphosphate + 4-Aminobenzoate <=> Diphosphate + Dihydropteroate

(7,8-dihydropterin-6-yl)methyl diphosphate:4-aminobenzoate 2-amino-4-hydroxy-7,8-dihydropteridine-6-methenyltransferase

Szeh_00456 K01633 folB R03504

7,8-Dihydroneopterin <=> Glycolaldehyde + 6-(Hydroxymethyl)-7,8-dihydropterin

7,8-dihydroneopterin glycolaldehyde-lyase [6-(hydroxymethyl)-7,8-dihydropterin-forming]

Szeh_00456 K01633 folB R11037

7,8-Dihydroneopterin + Oxygen <=> 7,8-Dihydroxanthopterin + Formate + Glycolaldehyde

7,8-dihydroneopterin:oxygen oxidoreductase

Szeh_00456 K01633 folB R11073

7,8-Dihydroneopterin <=> 7,8-Dihydromonapterin

7,8-dihydroneopterin 2'-epimerase

Szeh_00457 K00950 folK R03503

ATP + 6-(Hydroxymethyl)-7,8-dihydropterin <=> AMP + 6-Hydroxymethyl-7,8-dihydropterin diphosphate

ATP:6-hydroxymethyl-7,8-dihydropterin 6'-diphosphotransferase

Metabolic pathways 3 genes

Szeh_00455 Szeh_00456 Szeh_00457

show cofactors (H₂O, ATP, NAD⁺…) drag nodes · click an edge for the reaction

Locus	Product	KO	EC	Reactions
Szeh_00454	HD domain-containing protein	K06950 K06950	—	—
Szeh_00455	dihydropteroate synthase	K00796 folP	2.5.1.15	R03066,R03067
Szeh_00456	dihydroneopterin aldolase	K01633 folB	1.13.11.81,4.1.2.25,5.1.99.8	R03504,R11037,R11073
Szeh_00457	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase	K00950 folK	2.7.6.3	R03503