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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_CGIH01000009.1:131,825–137,510

Syntrophomonas zehnderi OL-4 Szehn · 5 genes
5
genes
5
KO-annotated
9
reactions
8
pathways

Activity by pathway — click to expand; ranked by genes involved

Glycine, serine and threonine metabolismMetabolism; Amino acid metabolism5 genes · 14 rxns
Szeh_00714 K00382 DLD, lpd, pdhD R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Szeh_00714 K00382 DLD, lpd, pdhD R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Szeh_00714 K00382 DLD, lpd, pdhD R01698
Dihydrolipoamide + NAD+ <=> Lipoamide + NADH + H+
dihydrolipoamide:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R03815
Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+
dihydrolipoylprotein:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R07618
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R08549
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating); 2-oxoglutarate dehydrogenase complex
Szeh_00715 K00283 gcvPB R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Szeh_00715 K00283 gcvPB R03425
Glycine + Lipoylprotein <=> [Protein]-S8-aminomethyldihydrolipoyllysine + CO2
glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)
Szeh_00716 K00282 gcvPA R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Szeh_00716 K00282 gcvPA R03425
Glycine + Lipoylprotein <=> [Protein]-S8-aminomethyldihydrolipoyllysine + CO2
glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)
Szeh_00717 K02437 gcvH, GCSH R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Szeh_00718 K00605 gcvT, AMT R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Szeh_00718 K00605 gcvT, AMT R02300
Folinic acid <=> 5,10-Methenyltetrahydrofolate + H2O
S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming)
Szeh_00718 K00605 gcvT, AMT R04125
[Protein]-S8-aminomethyldihydrolipoyllysine + Tetrahydrofolate <=> Dihydrolipoylprotein + 5,10-Methylenetetrahydrofolate + Ammonia
[protein]-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming)
Glyoxylate and dicarboxylate metabolismMetabolism; Carbohydrate metabolism5 genes · 14 rxns
Szeh_00714 K00382 DLD, lpd, pdhD R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Szeh_00714 K00382 DLD, lpd, pdhD R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Szeh_00714 K00382 DLD, lpd, pdhD R01698
Dihydrolipoamide + NAD+ <=> Lipoamide + NADH + H+
dihydrolipoamide:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R03815
Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+
dihydrolipoylprotein:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R07618
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R08549
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating); 2-oxoglutarate dehydrogenase complex
Szeh_00715 K00283 gcvPB R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Szeh_00715 K00283 gcvPB R03425
Glycine + Lipoylprotein <=> [Protein]-S8-aminomethyldihydrolipoyllysine + CO2
glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)
Szeh_00716 K00282 gcvPA R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Szeh_00716 K00282 gcvPA R03425
Glycine + Lipoylprotein <=> [Protein]-S8-aminomethyldihydrolipoyllysine + CO2
glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)
Szeh_00717 K02437 gcvH, GCSH R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Szeh_00718 K00605 gcvT, AMT R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Szeh_00718 K00605 gcvT, AMT R02300
Folinic acid <=> 5,10-Methenyltetrahydrofolate + H2O
S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming)
Szeh_00718 K00605 gcvT, AMT R04125
[Protein]-S8-aminomethyldihydrolipoyllysine + Tetrahydrofolate <=> Dihydrolipoylprotein + 5,10-Methylenetetrahydrofolate + Ammonia
[protein]-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming)
Glycolysis / GluconeogenesisMetabolism; Carbohydrate metabolism1 genes · 6 rxns
Szeh_00714 K00382 DLD, lpd, pdhD R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Szeh_00714 K00382 DLD, lpd, pdhD R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Szeh_00714 K00382 DLD, lpd, pdhD R01698
Dihydrolipoamide + NAD+ <=> Lipoamide + NADH + H+
dihydrolipoamide:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R03815
Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+
dihydrolipoylprotein:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R07618
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R08549
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating); 2-oxoglutarate dehydrogenase complex
Citrate cycle (TCA cycle)Metabolism; Carbohydrate metabolism1 genes · 6 rxns
Szeh_00714 K00382 DLD, lpd, pdhD R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Szeh_00714 K00382 DLD, lpd, pdhD R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Szeh_00714 K00382 DLD, lpd, pdhD R01698
Dihydrolipoamide + NAD+ <=> Lipoamide + NADH + H+
dihydrolipoamide:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R03815
Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+
dihydrolipoylprotein:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R07618
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R08549
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating); 2-oxoglutarate dehydrogenase complex
Valine, leucine and isoleucine degradationMetabolism; Amino acid metabolism1 genes · 6 rxns
Szeh_00714 K00382 DLD, lpd, pdhD R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Szeh_00714 K00382 DLD, lpd, pdhD R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Szeh_00714 K00382 DLD, lpd, pdhD R01698
Dihydrolipoamide + NAD+ <=> Lipoamide + NADH + H+
dihydrolipoamide:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R03815
Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+
dihydrolipoylprotein:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R07618
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R08549
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating); 2-oxoglutarate dehydrogenase complex
Pyruvate metabolismMetabolism; Carbohydrate metabolism1 genes · 6 rxns
Szeh_00714 K00382 DLD, lpd, pdhD R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Szeh_00714 K00382 DLD, lpd, pdhD R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Szeh_00714 K00382 DLD, lpd, pdhD R01698
Dihydrolipoamide + NAD+ <=> Lipoamide + NADH + H+
dihydrolipoamide:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R03815
Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+
dihydrolipoylprotein:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R07618
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R08549
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating); 2-oxoglutarate dehydrogenase complex
Propanoate metabolismMetabolism; Carbohydrate metabolism1 genes · 6 rxns
Szeh_00714 K00382 DLD, lpd, pdhD R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Szeh_00714 K00382 DLD, lpd, pdhD R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Szeh_00714 K00382 DLD, lpd, pdhD R01698
Dihydrolipoamide + NAD+ <=> Lipoamide + NADH + H+
dihydrolipoamide:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R03815
Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+
dihydrolipoylprotein:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R07618
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Szeh_00714 K00382 DLD, lpd, pdhD R08549
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating); 2-oxoglutarate dehydrogenase complex
One carbon pool by folateMetabolism; Metabolism of cofactors and vitamins1 genes · 3 rxns
Szeh_00718 K00605 gcvT, AMT R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Szeh_00718 K00605 gcvT, AMT R02300
Folinic acid <=> 5,10-Methenyltetrahydrofolate + H2O
S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming)
Szeh_00718 K00605 gcvT, AMT R04125
[Protein]-S8-aminomethyldihydrolipoyllysine + Tetrahydrofolate <=> Dihydrolipoylprotein + 5,10-Methylenetetrahydrofolate + Ammonia
[protein]-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming)

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 5 genes
Szeh_00714 Szeh_00715 Szeh_00716 Szeh_00717 Szeh_00718
Biosynthesis of secondary metabolites 5 genes
Szeh_00714 Szeh_00715 Szeh_00716 Szeh_00717 Szeh_00718
Map 01130 5 genes
Szeh_00714 Szeh_00715 Szeh_00716 Szeh_00717 Szeh_00718
Carbon metabolism 5 genes
Szeh_00714 Szeh_00715 Szeh_00716 Szeh_00717 Szeh_00718
Microbial metabolism in diverse environments 1 genes
Szeh_00714

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Szeh_00714 dihydrolipoyl dehydrogenase K00382 DLD, lpd, pdhD 1.8.1.4 R00209,R01221,R01698,R03815,R07618,R08549
Szeh_00715 aminomethyl-transferring glycine dehydrogenase subunit GcvPB K00283 gcvPB 1.4.4.2 R01221,R03425
Szeh_00716 aminomethyl-transferring glycine dehydrogenase subunit GcvPA K00282 gcvPA 1.4.4.2 R01221,R03425
Szeh_00717 glycine cleavage system protein GcvH K02437 gcvH, GCSH — R01221
Szeh_00718 glycine cleavage system aminomethyltransferase GcvT K00605 gcvT, AMT 2.1.2.10 R01221,R02300,R04125
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