Small Microbes Pathway Profiler

Domain Counts
Profiler Search and BLAST
CAZy ▾
CAZyme Browser CAzy - DBCAN (original) CAZyme protein counts Proteome Coverage Summary
Search ▾
Text search Domain display search
Pathways ▾
Nitrogen Fixation CANT-Hyd
UMAP
◀ domain architecture  ·  operons  ·  ❔ guide

Operon NC_008346.1:450,965–452,779

Syntrophomonas wolfei subsp. wolfei Goettingen · 2 genes
2
genes
2
KO-annotated
8
reactions
6
pathways

Activity by pathway — click to expand; ranked by genes involved

Valine, leucine and isoleucine biosynthesisMetabolism; Amino acid metabolism1 genes · 5 rxns
Swg_00367 K01704 leuD, IPMI-S R03896
(R)-2-Methylmalate <=> 2-Methylmaleate + H2O
(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)
Swg_00367 K01704 leuD, IPMI-S R03898
2-Methylmaleate + H2O <=> D-erythro-3-Methylmalate
2-methylmaleate hydratase; D-erythro-3-methylmalate hydro-lyase (2-methylmaleate-forming)
Swg_00367 K01704 leuD, IPMI-S R03968
alpha-Isopropylmalate <=> 2-Isopropylmaleate + H2O
2-isopropylmalate hydro-lyase
Swg_00367 K01704 leuD, IPMI-S R04001
(2R,3S)-3-Isopropylmalate <=> 2-Isopropylmaleate + H2O
3-isopropylmalate hydro-lyase
Swg_00367 K01704 leuD, IPMI-S R10170
(2R,3S)-3-Isopropylmalate <=> alpha-Isopropylmalate
(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
C5-Branched dibasic acid metabolismMetabolism; Carbohydrate metabolism1 genes · 5 rxns
Swg_00367 K01704 leuD, IPMI-S R03896
(R)-2-Methylmalate <=> 2-Methylmaleate + H2O
(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)
Swg_00367 K01704 leuD, IPMI-S R03898
2-Methylmaleate + H2O <=> D-erythro-3-Methylmalate
2-methylmaleate hydratase; D-erythro-3-methylmalate hydro-lyase (2-methylmaleate-forming)
Swg_00367 K01704 leuD, IPMI-S R03968
alpha-Isopropylmalate <=> 2-Isopropylmaleate + H2O
2-isopropylmalate hydro-lyase
Swg_00367 K01704 leuD, IPMI-S R04001
(2R,3S)-3-Isopropylmalate <=> 2-Isopropylmaleate + H2O
3-isopropylmalate hydro-lyase
Swg_00367 K01704 leuD, IPMI-S R10170
(2R,3S)-3-Isopropylmalate <=> alpha-Isopropylmalate
(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
Citrate cycle (TCA cycle)Metabolism; Carbohydrate metabolism1 genes · 3 rxns
Swg_00368 K00031 IDH1, IDH2, icd, IDP R00267
Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
isocitrate:NADP+ oxidoreductase (decarboxylating)
Swg_00368 K00031 IDH1, IDH2, icd, IDP R00268
Oxalosuccinate <=> 2-Oxoglutarate + CO2
oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
Swg_00368 K00031 IDH1, IDH2, icd, IDP R01899
Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
isocitrate:NADP+ oxidoreductase
Glutathione metabolismMetabolism; Metabolism of other amino acids1 genes · 3 rxns
Swg_00368 K00031 IDH1, IDH2, icd, IDP R00267
Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
isocitrate:NADP+ oxidoreductase (decarboxylating)
Swg_00368 K00031 IDH1, IDH2, icd, IDP R00268
Oxalosuccinate <=> 2-Oxoglutarate + CO2
oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
Swg_00368 K00031 IDH1, IDH2, icd, IDP R01899
Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
isocitrate:NADP+ oxidoreductase
Other carbon fixation pathwaysMetabolism; Energy metabolism1 genes · 3 rxns
Swg_00368 K00031 IDH1, IDH2, icd, IDP R00267
Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
isocitrate:NADP+ oxidoreductase (decarboxylating)
Swg_00368 K00031 IDH1, IDH2, icd, IDP R00268
Oxalosuccinate <=> 2-Oxoglutarate + CO2
oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
Swg_00368 K00031 IDH1, IDH2, icd, IDP R01899
Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
isocitrate:NADP+ oxidoreductase
PeroxisomeCellular Processes; Transport and catabolism1 genes · 3 rxns
Swg_00368 K00031 IDH1, IDH2, icd, IDP R00267
Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
isocitrate:NADP+ oxidoreductase (decarboxylating)
Swg_00368 K00031 IDH1, IDH2, icd, IDP R00268
Oxalosuccinate <=> 2-Oxoglutarate + CO2
oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
Swg_00368 K00031 IDH1, IDH2, icd, IDP R01899
Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
isocitrate:NADP+ oxidoreductase

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 2 genes
Swg_00367 Swg_00368
Biosynthesis of secondary metabolites 2 genes
Swg_00367 Swg_00368
2-Oxocarboxylic acid metabolism 2 genes
Swg_00367 Swg_00368
Biosynthesis of amino acids 2 genes
Swg_00367 Swg_00368
Microbial metabolism in diverse environments 1 genes
Swg_00368
Map 01130 1 genes
Swg_00368
Carbon metabolism 1 genes
Swg_00368

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Swg_00367 3-isopropylmalate dehydratase small subunit K01704 leuD, IPMI-S 4.2.1.33,4.2.1.35 R03896,R03898,R03968,R04001,R10170
Swg_00368 NADP-dependent isocitrate dehydrogenase K00031 IDH1, IDH2, icd, IDP 1.1.1.42 R00267,R00268,R01899
↑ Top




v1.00 @copyright 2026 UCLA