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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NC_008346.1:2,036,822–2,038,904

Syntrophomonas wolfei subsp. wolfei Goettingen · 2 genes
2
genes
2
KO-annotated
10
reactions
2
pathways

Activity by pathway — click to expand; ranked by genes involved

Purine metabolismMetabolism; Nucleotide metabolism2 genes · 10 rxns
Swg_01817 K01951 guaA, GMPS R01230
ATP + Xanthosine 5'-phosphate + Ammonia <=> AMP + Diphosphate + GMP
xanthosine-5'-phosphate:ammonia ligase (AMP-forming)
Swg_01817 K01951 guaA, GMPS R01231
ATP + Xanthosine 5'-phosphate + L-Glutamine + H2O <=> AMP + Diphosphate + GMP + L-Glutamate
xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)
Swg_01817 K01951 guaA, GMPS R08244
6-Thioxanthine 5'-monophosphate + ATP + L-Glutamine + H2O <=> 6-Thioguanosine monophosphate + AMP + Diphosphate + L-Glutamate
6-thioxanthine 5'-monophosphate:L-glutamine amido-ligase (AMP-forming)
Swg_01818 K00760 hprT, hpt, HPRT1 R00190
AMP + Diphosphate <=> Adenine + 5-Phospho-alpha-D-ribose 1-diphosphate
AMP:diphosphate phospho-D-ribosyltransferase
Swg_01818 K00760 hprT, hpt, HPRT1 R01132
IMP + Diphosphate <=> Hypoxanthine + 5-Phospho-alpha-D-ribose 1-diphosphate
IMP:diphosphate phospho-D-ribosyltransferase
Swg_01818 K00760 hprT, hpt, HPRT1 R01229
GMP + Diphosphate <=> Guanine + 5-Phospho-alpha-D-ribose 1-diphosphate
GMP:diphosphate 5-phospho-alpha-D-ribosyltransferase
Swg_01818 K00760 hprT, hpt, HPRT1 R02142
Xanthosine 5'-phosphate + Diphosphate <=> Xanthine + 5-Phospho-alpha-D-ribose 1-diphosphate
XMP:pyrophosphate phosphoribosyltransferase
Swg_01818 K00760 hprT, hpt, HPRT1 R08237
6-Mercaptopurine + 5-Phospho-alpha-D-ribose 1-diphosphate <=> 6-Thioinosine-5'-monophosphate + Diphosphate
6-thioinosine 5'-monophosphate:diphosphate phospho-D-ribosyltransferase
Swg_01818 K00760 hprT, hpt, HPRT1 R08238
6-Methylmercaptopurine + 5-Phospho-alpha-D-ribose 1-diphosphate <=> 6-Methylthiopurine 5'-monophosphate ribonucleotide + Diphosphate
6-methylthiopurine 5'-monophosphate ribonucleotide:diphosphate phospho-D-ribosyltransferase
Swg_01818 K00760 hprT, hpt, HPRT1 R08245
Thioguanine + 5-Phospho-alpha-D-ribose 1-diphosphate <=> 6-Thioguanosine monophosphate + Diphosphate
6-thioguanosine monophosphate:diphosphate phospho-D-ribosyltransferase
Drug metabolism - other enzymesMetabolism; Xenobiotics biodegradation and metabolism2 genes · 10 rxns
Swg_01817 K01951 guaA, GMPS R01230
ATP + Xanthosine 5'-phosphate + Ammonia <=> AMP + Diphosphate + GMP
xanthosine-5'-phosphate:ammonia ligase (AMP-forming)
Swg_01817 K01951 guaA, GMPS R01231
ATP + Xanthosine 5'-phosphate + L-Glutamine + H2O <=> AMP + Diphosphate + GMP + L-Glutamate
xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)
Swg_01817 K01951 guaA, GMPS R08244
6-Thioxanthine 5'-monophosphate + ATP + L-Glutamine + H2O <=> 6-Thioguanosine monophosphate + AMP + Diphosphate + L-Glutamate
6-thioxanthine 5'-monophosphate:L-glutamine amido-ligase (AMP-forming)
Swg_01818 K00760 hprT, hpt, HPRT1 R00190
AMP + Diphosphate <=> Adenine + 5-Phospho-alpha-D-ribose 1-diphosphate
AMP:diphosphate phospho-D-ribosyltransferase
Swg_01818 K00760 hprT, hpt, HPRT1 R01132
IMP + Diphosphate <=> Hypoxanthine + 5-Phospho-alpha-D-ribose 1-diphosphate
IMP:diphosphate phospho-D-ribosyltransferase
Swg_01818 K00760 hprT, hpt, HPRT1 R01229
GMP + Diphosphate <=> Guanine + 5-Phospho-alpha-D-ribose 1-diphosphate
GMP:diphosphate 5-phospho-alpha-D-ribosyltransferase
Swg_01818 K00760 hprT, hpt, HPRT1 R02142
Xanthosine 5'-phosphate + Diphosphate <=> Xanthine + 5-Phospho-alpha-D-ribose 1-diphosphate
XMP:pyrophosphate phosphoribosyltransferase
Swg_01818 K00760 hprT, hpt, HPRT1 R08237
6-Mercaptopurine + 5-Phospho-alpha-D-ribose 1-diphosphate <=> 6-Thioinosine-5'-monophosphate + Diphosphate
6-thioinosine 5'-monophosphate:diphosphate phospho-D-ribosyltransferase
Swg_01818 K00760 hprT, hpt, HPRT1 R08238
6-Methylmercaptopurine + 5-Phospho-alpha-D-ribose 1-diphosphate <=> 6-Methylthiopurine 5'-monophosphate ribonucleotide + Diphosphate
6-methylthiopurine 5'-monophosphate ribonucleotide:diphosphate phospho-D-ribosyltransferase
Swg_01818 K00760 hprT, hpt, HPRT1 R08245
Thioguanine + 5-Phospho-alpha-D-ribose 1-diphosphate <=> 6-Thioguanosine monophosphate + Diphosphate
6-thioguanosine monophosphate:diphosphate phospho-D-ribosyltransferase

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 2 genes
Swg_01817 Swg_01818
Biosynthesis of secondary metabolites 1 genes
Swg_01818

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Swg_01817 glutamine-hydrolyzing GMP synthase K01951 guaA, GMPS 6.3.5.2 R01230,R01231,R08244
Swg_01818 hypoxanthine phosphoribosyltransferase K00760 hprT, hpt, HPRT1 2.4.2.8 R00190,R01132,R01229,R02142,R08237,R08238,R08245
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