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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NC_008346.1:2,464,797–2,469,899

Syntrophomonas wolfei subsp. wolfei Goettingen · 4 genes
4
genes
4
KO-annotated
14
reactions
6
pathways

Activity by pathway — click to expand; ranked by genes involved

Valine, leucine and isoleucine biosynthesisMetabolism; Amino acid metabolism4 genes · 21 rxns
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Swg_02182 K01687 ilvD R01209
2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O
2,3-dihydroxy-3-methylbutanoate hydro-lyase
Swg_02182 K01687 ilvD R04441
(R)-2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O
(R)-2,3-dihydroxy-3-methylbutanoate hydro-lyase
Swg_02182 K01687 ilvD R05070
(R)-2,3-Dihydroxy-3-methylpentanoate <=> (S)-3-Methyl-2-oxopentanoic acid + H2O
(R)-2,3-dihydroxy-3-methylpentanoate hydro-lyase
Swg_02183 K00826 E2.6.1.42, ilvE R01090
L-Leucine + 2-Oxoglutarate <=> 4-Methyl-2-oxopentanoate + L-Glutamate
L-leucine:2-oxoglutarate aminotransferase
Swg_02183 K00826 E2.6.1.42, ilvE R01214
L-Valine + 2-Oxoglutarate <=> 3-Methyl-2-oxobutanoic acid + L-Glutamate
L-valine:2-oxoglutarate aminotransferase
Swg_02183 K00826 E2.6.1.42, ilvE R02199
L-Isoleucine + 2-Oxoglutarate <=> (S)-3-Methyl-2-oxopentanoic acid + L-Glutamate
L-isoleucine:2-oxoglutarate aminotransferase
Swg_02183 K00826 E2.6.1.42, ilvE R10991
(S)-2-Aminobutanoate + 2-Oxoglutarate <=> 2-Oxobutanoate + L-Glutamate
2-aminobutanoate:2-oxoglutarate aminotransferase
Pantothenate and CoA biosynthesisMetabolism; Metabolism of cofactors and vitamins4 genes · 21 rxns
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Swg_02182 K01687 ilvD R01209
2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O
2,3-dihydroxy-3-methylbutanoate hydro-lyase
Swg_02182 K01687 ilvD R04441
(R)-2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O
(R)-2,3-dihydroxy-3-methylbutanoate hydro-lyase
Swg_02182 K01687 ilvD R05070
(R)-2,3-Dihydroxy-3-methylpentanoate <=> (S)-3-Methyl-2-oxopentanoic acid + H2O
(R)-2,3-dihydroxy-3-methylpentanoate hydro-lyase
Swg_02183 K00826 E2.6.1.42, ilvE R01090
L-Leucine + 2-Oxoglutarate <=> 4-Methyl-2-oxopentanoate + L-Glutamate
L-leucine:2-oxoglutarate aminotransferase
Swg_02183 K00826 E2.6.1.42, ilvE R01214
L-Valine + 2-Oxoglutarate <=> 3-Methyl-2-oxobutanoic acid + L-Glutamate
L-valine:2-oxoglutarate aminotransferase
Swg_02183 K00826 E2.6.1.42, ilvE R02199
L-Isoleucine + 2-Oxoglutarate <=> (S)-3-Methyl-2-oxopentanoic acid + L-Glutamate
L-isoleucine:2-oxoglutarate aminotransferase
Swg_02183 K00826 E2.6.1.42, ilvE R10991
(S)-2-Aminobutanoate + 2-Oxoglutarate <=> 2-Oxobutanoate + L-Glutamate
2-aminobutanoate:2-oxoglutarate aminotransferase
Butanoate metabolismMetabolism; Carbohydrate metabolism2 genes · 14 rxns
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
C5-Branched dibasic acid metabolismMetabolism; Carbohydrate metabolism2 genes · 14 rxns
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Swg_02180 K01653 E2.2.1.6S, ilvH, ilvN R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Swg_02181 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Cysteine and methionine metabolismMetabolism; Amino acid metabolism1 genes · 4 rxns
Swg_02183 K00826 E2.6.1.42, ilvE R01090
L-Leucine + 2-Oxoglutarate <=> 4-Methyl-2-oxopentanoate + L-Glutamate
L-leucine:2-oxoglutarate aminotransferase
Swg_02183 K00826 E2.6.1.42, ilvE R01214
L-Valine + 2-Oxoglutarate <=> 3-Methyl-2-oxobutanoic acid + L-Glutamate
L-valine:2-oxoglutarate aminotransferase
Swg_02183 K00826 E2.6.1.42, ilvE R02199
L-Isoleucine + 2-Oxoglutarate <=> (S)-3-Methyl-2-oxopentanoic acid + L-Glutamate
L-isoleucine:2-oxoglutarate aminotransferase
Swg_02183 K00826 E2.6.1.42, ilvE R10991
(S)-2-Aminobutanoate + 2-Oxoglutarate <=> 2-Oxobutanoate + L-Glutamate
2-aminobutanoate:2-oxoglutarate aminotransferase
Valine, leucine and isoleucine degradationMetabolism; Amino acid metabolism1 genes · 4 rxns
Swg_02183 K00826 E2.6.1.42, ilvE R01090
L-Leucine + 2-Oxoglutarate <=> 4-Methyl-2-oxopentanoate + L-Glutamate
L-leucine:2-oxoglutarate aminotransferase
Swg_02183 K00826 E2.6.1.42, ilvE R01214
L-Valine + 2-Oxoglutarate <=> 3-Methyl-2-oxobutanoic acid + L-Glutamate
L-valine:2-oxoglutarate aminotransferase
Swg_02183 K00826 E2.6.1.42, ilvE R02199
L-Isoleucine + 2-Oxoglutarate <=> (S)-3-Methyl-2-oxopentanoic acid + L-Glutamate
L-isoleucine:2-oxoglutarate aminotransferase
Swg_02183 K00826 E2.6.1.42, ilvE R10991
(S)-2-Aminobutanoate + 2-Oxoglutarate <=> 2-Oxobutanoate + L-Glutamate
2-aminobutanoate:2-oxoglutarate aminotransferase

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 4 genes
Swg_02180 Swg_02181 Swg_02182 Swg_02183
Biosynthesis of secondary metabolites 4 genes
Swg_02180 Swg_02181 Swg_02182 Swg_02183
Map 01130 4 genes
Swg_02180 Swg_02181 Swg_02182 Swg_02183
2-Oxocarboxylic acid metabolism 4 genes
Swg_02180 Swg_02181 Swg_02182 Swg_02183
Biosynthesis of amino acids 4 genes
Swg_02180 Swg_02181 Swg_02182 Swg_02183

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Swg_02180 acetolactate synthase small subunit K01653 E2.2.1.6S, ilvH, ilvN 2.2.1.6 R00006,R00014,R00226,R03050,R04672,R04673,R08648
Swg_02181 biosynthetic-type acetolactate synthase large subunit K01652 E2.2.1.6L, ilvB, ilvG, ilvI 2.2.1.6 R00006,R00014,R00226,R03050,R04672,R04673,R08648
Swg_02182 dihydroxy-acid dehydratase K01687 ilvD 4.2.1.9 R01209,R04441,R05070
Swg_02183 branched-chain-amino-acid transaminase K00826 E2.6.1.42, ilvE 2.6.1.42 R01090,R01214,R02199,R10991
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