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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_CM161534.1:481,663–486,178

Syntrophomonas wolfei methylbutyratica 4J5 · 4 genes
4
genes
4
KO-annotated
15
reactions
8
pathways

Activity by pathway — click to expand; ranked by genes involved

Valine, leucine and isoleucine biosynthesisMetabolism; Amino acid metabolism2 genes · 16 rxns
Swm_00415 K01703 leuC, IPMI-L R03896
(R)-2-Methylmalate <=> 2-Methylmaleate + H2O
(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_00415 K01703 leuC, IPMI-L R03898
2-Methylmaleate + H2O <=> D-erythro-3-Methylmalate
2-methylmaleate hydratase; D-erythro-3-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_00415 K01703 leuC, IPMI-L R03968
alpha-Isopropylmalate <=> 2-Isopropylmaleate + H2O
2-isopropylmalate hydro-lyase
Swm_00415 K01703 leuC, IPMI-L R04001
(2R,3S)-3-Isopropylmalate <=> 2-Isopropylmaleate + H2O
3-isopropylmalate hydro-lyase
Swm_00415 K01703 leuC, IPMI-L R08620
2-(2'-Methylthio)ethylmalic acid <=> 3-(2'-Methylthio)ethylmalic acid
2-(2'-methylthio)ethylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R08624
2-(3'-Methylthio)propylmalic acid <=> 3-(3'-Methylthio)propylmalic acid
2-(3'-methylthio)propylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R08628
2-(4'-Methylthio)butylmalic acid <=> 3-(4'-Methylthio)butylmalic acid
2-(3'-methylthio)butylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R08634
2-(5'-Methylthio)pentylmalic acid <=> 3-(5'-Methylthio)pentylmalic acid
2-(3'-methylthio)pentylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R08641
2-(6'-Methylthio)hexylmalic acid <=> 3-(6'-Methylthio)hexylmalic acid
2-(3'-methylthio)hexylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R08645
2-(7'-Methylthio)heptylmalic acid <=> 3-(7'-Methylthio)heptylmalic acid
2-(3'-methylthio)heptylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R10170
(2R,3S)-3-Isopropylmalate <=> alpha-Isopropylmalate
(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
Swm_00416 K01704 leuD, IPMI-S R03896
(R)-2-Methylmalate <=> 2-Methylmaleate + H2O
(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_00416 K01704 leuD, IPMI-S R03898
2-Methylmaleate + H2O <=> D-erythro-3-Methylmalate
2-methylmaleate hydratase; D-erythro-3-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_00416 K01704 leuD, IPMI-S R03968
alpha-Isopropylmalate <=> 2-Isopropylmaleate + H2O
2-isopropylmalate hydro-lyase
Swm_00416 K01704 leuD, IPMI-S R04001
(2R,3S)-3-Isopropylmalate <=> 2-Isopropylmaleate + H2O
3-isopropylmalate hydro-lyase
Swm_00416 K01704 leuD, IPMI-S R10170
(2R,3S)-3-Isopropylmalate <=> alpha-Isopropylmalate
(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
C5-Branched dibasic acid metabolismMetabolism; Carbohydrate metabolism2 genes · 16 rxns
Swm_00415 K01703 leuC, IPMI-L R03896
(R)-2-Methylmalate <=> 2-Methylmaleate + H2O
(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_00415 K01703 leuC, IPMI-L R03898
2-Methylmaleate + H2O <=> D-erythro-3-Methylmalate
2-methylmaleate hydratase; D-erythro-3-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_00415 K01703 leuC, IPMI-L R03968
alpha-Isopropylmalate <=> 2-Isopropylmaleate + H2O
2-isopropylmalate hydro-lyase
Swm_00415 K01703 leuC, IPMI-L R04001
(2R,3S)-3-Isopropylmalate <=> 2-Isopropylmaleate + H2O
3-isopropylmalate hydro-lyase
Swm_00415 K01703 leuC, IPMI-L R08620
2-(2'-Methylthio)ethylmalic acid <=> 3-(2'-Methylthio)ethylmalic acid
2-(2'-methylthio)ethylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R08624
2-(3'-Methylthio)propylmalic acid <=> 3-(3'-Methylthio)propylmalic acid
2-(3'-methylthio)propylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R08628
2-(4'-Methylthio)butylmalic acid <=> 3-(4'-Methylthio)butylmalic acid
2-(3'-methylthio)butylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R08634
2-(5'-Methylthio)pentylmalic acid <=> 3-(5'-Methylthio)pentylmalic acid
2-(3'-methylthio)pentylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R08641
2-(6'-Methylthio)hexylmalic acid <=> 3-(6'-Methylthio)hexylmalic acid
2-(3'-methylthio)hexylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R08645
2-(7'-Methylthio)heptylmalic acid <=> 3-(7'-Methylthio)heptylmalic acid
2-(3'-methylthio)heptylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R10170
(2R,3S)-3-Isopropylmalate <=> alpha-Isopropylmalate
(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
Swm_00416 K01704 leuD, IPMI-S R03896
(R)-2-Methylmalate <=> 2-Methylmaleate + H2O
(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_00416 K01704 leuD, IPMI-S R03898
2-Methylmaleate + H2O <=> D-erythro-3-Methylmalate
2-methylmaleate hydratase; D-erythro-3-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_00416 K01704 leuD, IPMI-S R03968
alpha-Isopropylmalate <=> 2-Isopropylmaleate + H2O
2-isopropylmalate hydro-lyase
Swm_00416 K01704 leuD, IPMI-S R04001
(2R,3S)-3-Isopropylmalate <=> 2-Isopropylmaleate + H2O
3-isopropylmalate hydro-lyase
Swm_00416 K01704 leuD, IPMI-S R10170
(2R,3S)-3-Isopropylmalate <=> alpha-Isopropylmalate
(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
Pyruvate metabolismMetabolism; Carbohydrate metabolism1 genes · 1 rxns
Swm_00414 K02594 nifV R00271
Acetyl-CoA + H2O + 2-Oxoglutarate <=> (R)-2-Hydroxybutane-1,2,4-tricarboxylate + CoA
acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
Glucosinolate biosynthesisMetabolism; Biosynthesis of other secondary metabolites1 genes · 11 rxns
Swm_00415 K01703 leuC, IPMI-L R03896
(R)-2-Methylmalate <=> 2-Methylmaleate + H2O
(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_00415 K01703 leuC, IPMI-L R03898
2-Methylmaleate + H2O <=> D-erythro-3-Methylmalate
2-methylmaleate hydratase; D-erythro-3-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_00415 K01703 leuC, IPMI-L R03968
alpha-Isopropylmalate <=> 2-Isopropylmaleate + H2O
2-isopropylmalate hydro-lyase
Swm_00415 K01703 leuC, IPMI-L R04001
(2R,3S)-3-Isopropylmalate <=> 2-Isopropylmaleate + H2O
3-isopropylmalate hydro-lyase
Swm_00415 K01703 leuC, IPMI-L R08620
2-(2'-Methylthio)ethylmalic acid <=> 3-(2'-Methylthio)ethylmalic acid
2-(2'-methylthio)ethylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R08624
2-(3'-Methylthio)propylmalic acid <=> 3-(3'-Methylthio)propylmalic acid
2-(3'-methylthio)propylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R08628
2-(4'-Methylthio)butylmalic acid <=> 3-(4'-Methylthio)butylmalic acid
2-(3'-methylthio)butylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R08634
2-(5'-Methylthio)pentylmalic acid <=> 3-(5'-Methylthio)pentylmalic acid
2-(3'-methylthio)pentylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R08641
2-(6'-Methylthio)hexylmalic acid <=> 3-(6'-Methylthio)hexylmalic acid
2-(3'-methylthio)hexylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R08645
2-(7'-Methylthio)heptylmalic acid <=> 3-(7'-Methylthio)heptylmalic acid
2-(3'-methylthio)heptylmalate hydroxymutase
Swm_00415 K01703 leuC, IPMI-L R10170
(2R,3S)-3-Isopropylmalate <=> alpha-Isopropylmalate
(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
Citrate cycle (TCA cycle)Metabolism; Carbohydrate metabolism1 genes · 3 rxns
Swm_00417 K00031 IDH1, IDH2, icd, IDP R00267
Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
isocitrate:NADP+ oxidoreductase (decarboxylating)
Swm_00417 K00031 IDH1, IDH2, icd, IDP R00268
Oxalosuccinate <=> 2-Oxoglutarate + CO2
oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
Swm_00417 K00031 IDH1, IDH2, icd, IDP R01899
Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
isocitrate:NADP+ oxidoreductase
Glutathione metabolismMetabolism; Metabolism of other amino acids1 genes · 3 rxns
Swm_00417 K00031 IDH1, IDH2, icd, IDP R00267
Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
isocitrate:NADP+ oxidoreductase (decarboxylating)
Swm_00417 K00031 IDH1, IDH2, icd, IDP R00268
Oxalosuccinate <=> 2-Oxoglutarate + CO2
oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
Swm_00417 K00031 IDH1, IDH2, icd, IDP R01899
Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
isocitrate:NADP+ oxidoreductase
Other carbon fixation pathwaysMetabolism; Energy metabolism1 genes · 3 rxns
Swm_00417 K00031 IDH1, IDH2, icd, IDP R00267
Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
isocitrate:NADP+ oxidoreductase (decarboxylating)
Swm_00417 K00031 IDH1, IDH2, icd, IDP R00268
Oxalosuccinate <=> 2-Oxoglutarate + CO2
oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
Swm_00417 K00031 IDH1, IDH2, icd, IDP R01899
Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
isocitrate:NADP+ oxidoreductase
PeroxisomeCellular Processes; Transport and catabolism1 genes · 3 rxns
Swm_00417 K00031 IDH1, IDH2, icd, IDP R00267
Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
isocitrate:NADP+ oxidoreductase (decarboxylating)
Swm_00417 K00031 IDH1, IDH2, icd, IDP R00268
Oxalosuccinate <=> 2-Oxoglutarate + CO2
oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
Swm_00417 K00031 IDH1, IDH2, icd, IDP R01899
Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
isocitrate:NADP+ oxidoreductase

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 3 genes
Swm_00415 Swm_00416 Swm_00417
Biosynthesis of secondary metabolites 3 genes
Swm_00415 Swm_00416 Swm_00417
2-Oxocarboxylic acid metabolism 3 genes
Swm_00415 Swm_00416 Swm_00417
Biosynthesis of amino acids 3 genes
Swm_00415 Swm_00416 Swm_00417
Microbial metabolism in diverse environments 1 genes
Swm_00417
Map 01130 1 genes
Swm_00417
Carbon metabolism 1 genes
Swm_00417

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Swm_00414 homocitrate synthase K02594 nifV 2.3.3.14 R00271
Swm_00415 3-isopropylmalate dehydratase large subunit K01703 leuC, IPMI-L 4.2.1.33,4.2.1.35 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170
Swm_00416 3-isopropylmalate dehydratase small subunit K01704 leuD, IPMI-S 4.2.1.33,4.2.1.35 R03896,R03898,R03968,R04001,R10170
Swm_00417 NADP-dependent isocitrate dehydrogenase K00031 IDH1, IDH2, icd, IDP 1.1.1.42 R00267,R00268,R01899
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