Reaction Activity

◀ domain architecture · operons · ❔ guide

Operon NZ_CM161534.1:519,194–523,416

Syntrophomonas wolfei methylbutyratica 4J5 · 4 genes

genes

KO-annotated

reactions

pathways

Activity by pathway — click to expand; ranked by genes involved

Butanoate metabolismMetabolism; Carbohydrate metabolism4 genes · 26 rxns

Swm_00448 K00074 paaH, hbd, fadB, mmgB R01976

(S)-3-Hydroxybutanoyl-CoA + NADP+ <=> Acetoacetyl-CoA + NADPH + H+

(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase

Swm_00448 K00074 paaH, hbd, fadB, mmgB R05576

3-Hydroxybutanoyl-CoA + NADP+ <=> Acetoacetyl-CoA + NADPH + H+

(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase

Swm_00448 K00074 paaH, hbd, fadB, mmgB R06941

(3S)-3-Hydroxyadipyl-CoA + NAD+ <=> 3-Oxoadipyl-CoA + NADH + H+

(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase

Swm_00449 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Swm_00449 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Swm_00449 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Swm_00450 K00626 ACAT, atoB R00238

2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA

acetyl-CoA:acetyl-CoA C-acetyltransferase

Swm_00450 K00626 ACAT, atoB R01177

Acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA

butanoyl-CoA:acetyl-CoA C-butanoyltransferase

Swm_00451 K00248 ACADS, bcd R01175

Butanoyl-CoA + FAD <=> FADH2 + Crotonoyl-CoA

butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Swm_00451 K00248 ACADS, bcd R01178

Short-chain acyl-CoA + Electron-transferring flavoprotein <=> Short-chain trans-2,3-dehydroacyl-CoA + Reduced electron-transferring flavoprotein

short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Swm_00451 K00248 ACADS, bcd R02661

2-Methylpropanoyl-CoA + Acceptor <=> 2-Methylprop-2-enoyl-CoA + Reduced acceptor

2-methylpropanoyl-CoA:(acceptor) 2,3-oxidoreductase

Swm_00451 K00248 ACADS, bcd R03172

(S)-2-Methylbutanoyl-CoA + Acceptor <=> 2-Methylbut-2-enoyl-CoA + Reduced acceptor

(S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase

Swm_00451 K00248 ACADS, bcd R04751

Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2

hexanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Benzoate degradationMetabolism; Xenobiotics biodegradation and metabolism3 genes · 21 rxns

Swm_00448 K00074 paaH, hbd, fadB, mmgB R01976

(S)-3-Hydroxybutanoyl-CoA + NADP+ <=> Acetoacetyl-CoA + NADPH + H+

(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase

Swm_00448 K00074 paaH, hbd, fadB, mmgB R05576

3-Hydroxybutanoyl-CoA + NADP+ <=> Acetoacetyl-CoA + NADPH + H+

(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase

Swm_00448 K00074 paaH, hbd, fadB, mmgB R06941

(3S)-3-Hydroxyadipyl-CoA + NAD+ <=> 3-Oxoadipyl-CoA + NADH + H+

(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase

Swm_00449 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Swm_00449 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Swm_00449 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Swm_00450 K00626 ACAT, atoB R00238

2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA

acetyl-CoA:acetyl-CoA C-acetyltransferase

Swm_00450 K00626 ACAT, atoB R01177

Acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA

butanoyl-CoA:acetyl-CoA C-butanoyltransferase

Fatty acid degradationMetabolism; Lipid metabolism3 genes · 23 rxns

Swm_00449 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Swm_00449 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Swm_00449 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Swm_00450 K00626 ACAT, atoB R00238

2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA

acetyl-CoA:acetyl-CoA C-acetyltransferase

Swm_00450 K00626 ACAT, atoB R01177

Acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA

butanoyl-CoA:acetyl-CoA C-butanoyltransferase

Swm_00451 K00248 ACADS, bcd R01175

Butanoyl-CoA + FAD <=> FADH2 + Crotonoyl-CoA

butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Swm_00451 K00248 ACADS, bcd R01178

Short-chain acyl-CoA + Electron-transferring flavoprotein <=> Short-chain trans-2,3-dehydroacyl-CoA + Reduced electron-transferring flavoprotein

short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Swm_00451 K00248 ACADS, bcd R02661

2-Methylpropanoyl-CoA + Acceptor <=> 2-Methylprop-2-enoyl-CoA + Reduced acceptor

2-methylpropanoyl-CoA:(acceptor) 2,3-oxidoreductase

Swm_00451 K00248 ACADS, bcd R03172

(S)-2-Methylbutanoyl-CoA + Acceptor <=> 2-Methylbut-2-enoyl-CoA + Reduced acceptor

(S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase

Swm_00451 K00248 ACADS, bcd R04751

Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2

hexanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Valine, leucine and isoleucine degradationMetabolism; Amino acid metabolism3 genes · 23 rxns

Swm_00449 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Swm_00449 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Swm_00449 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Swm_00450 K00626 ACAT, atoB R00238

2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA

acetyl-CoA:acetyl-CoA C-acetyltransferase

Swm_00450 K00626 ACAT, atoB R01177

Acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA

butanoyl-CoA:acetyl-CoA C-butanoyltransferase

Swm_00451 K00248 ACADS, bcd R01175

Butanoyl-CoA + FAD <=> FADH2 + Crotonoyl-CoA

butanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Swm_00451 K00248 ACADS, bcd R01178

Short-chain acyl-CoA + Electron-transferring flavoprotein <=> Short-chain trans-2,3-dehydroacyl-CoA + Reduced electron-transferring flavoprotein

short-chain acyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Swm_00451 K00248 ACADS, bcd R02661

2-Methylpropanoyl-CoA + Acceptor <=> 2-Methylprop-2-enoyl-CoA + Reduced acceptor

2-methylpropanoyl-CoA:(acceptor) 2,3-oxidoreductase

Swm_00451 K00248 ACADS, bcd R03172

(S)-2-Methylbutanoyl-CoA + Acceptor <=> 2-Methylbut-2-enoyl-CoA + Reduced acceptor

(S)-2-methylbutanoyl-CoA:acceptor 2,3-oxidoreductase

Swm_00451 K00248 ACADS, bcd R04751

Hexanoyl-CoA + FAD <=> trans-Hex-2-enoyl-CoA + FADH2

hexanoyl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase

Phenylalanine metabolismMetabolism; Amino acid metabolism2 genes · 19 rxns

Swm_00448 K00074 paaH, hbd, fadB, mmgB R01976

(S)-3-Hydroxybutanoyl-CoA + NADP+ <=> Acetoacetyl-CoA + NADPH + H+

(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase

Swm_00448 K00074 paaH, hbd, fadB, mmgB R05576

3-Hydroxybutanoyl-CoA + NADP+ <=> Acetoacetyl-CoA + NADPH + H+

(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase

Swm_00448 K00074 paaH, hbd, fadB, mmgB R06941

(3S)-3-Hydroxyadipyl-CoA + NAD+ <=> 3-Oxoadipyl-CoA + NADH + H+

(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase

Swm_00449 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Swm_00449 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Swm_00449 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Propanoate metabolismMetabolism; Carbohydrate metabolism2 genes · 18 rxns

Swm_00449 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Swm_00449 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Swm_00449 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Swm_00450 K00626 ACAT, atoB R00238

2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA

acetyl-CoA:acetyl-CoA C-acetyltransferase

Swm_00450 K00626 ACAT, atoB R01177

Acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA

butanoyl-CoA:acetyl-CoA C-butanoyltransferase

Tryptophan metabolismMetabolism; Amino acid metabolism2 genes · 18 rxns

Swm_00449 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Swm_00449 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Swm_00449 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Swm_00450 K00626 ACAT, atoB R00238

2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA

acetyl-CoA:acetyl-CoA C-acetyltransferase

Swm_00450 K00626 ACAT, atoB R01177

Acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA

butanoyl-CoA:acetyl-CoA C-butanoyltransferase

Lysine degradationMetabolism; Amino acid metabolism2 genes · 18 rxns

Swm_00449 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Swm_00449 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Swm_00449 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Swm_00450 K00626 ACAT, atoB R00238

2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA

acetyl-CoA:acetyl-CoA C-acetyltransferase

Swm_00450 K00626 ACAT, atoB R01177

Acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA

butanoyl-CoA:acetyl-CoA C-butanoyltransferase

Aminobenzoate degradationMetabolism; Xenobiotics biodegradation and metabolism1 genes · 16 rxns

Swm_00449 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Swm_00449 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Swm_00449 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Limonene degradationMetabolism; Metabolism of terpenoids and polyketides1 genes · 16 rxns

Swm_00449 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Swm_00449 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Swm_00449 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Caprolactam degradationMetabolism; Xenobiotics biodegradation and metabolism1 genes · 16 rxns

Swm_00449 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Swm_00449 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Swm_00449 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

beta-Alanine metabolismMetabolism; Metabolism of other amino acids1 genes · 16 rxns

Swm_00449 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Swm_00449 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Swm_00449 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Pathway 002811 genes · 16 rxns

Swm_00449 K01692 paaF, echA R03026

(S)-3-Hydroxybutanoyl-CoA <=> Crotonoyl-CoA + H2O

(S)-3-hydroxybutanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R03045

3-Hydroxypropionyl-CoA <=> Propenoyl-CoA + H2O

3-hydroxypropionyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04137

3-Hydroxyisovaleryl-CoA <=> 3-Methylcrotonyl-CoA + H2O

3-hydroxyisovaleryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04170

(S)-3-Hydroxydodecanoyl-CoA <=> 2-trans-Dodecenoyl-CoA + H2O

(S)-3-hydroxydodecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04204

(2S,3S)-3-Hydroxy-2-methylbutanoyl-CoA <=> 2-Methylbut-2-enoyl-CoA + H2O

(2S,3S)-3-hydroxy-2-methylbutanoyl-CoA hydro-liase

Swm_00449 K01692 paaF, echA R04224

2-Methylprop-2-enoyl-CoA + H2O <=> (S)-3-Hydroxyisobutyryl-CoA

(S)-3-hydroxyisobutyryl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04738

(S)-3-Hydroxyhexadecanoyl-CoA <=> trans-Hexadec-2-enoyl-CoA + H2O

(S)-3-hydroxyhexadecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04740

(S)-3-Hydroxytetradecanoyl-CoA <=> trans-Tetradec-2-enoyl-CoA + H2O

(S)-3-hydroxytetradecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04744

(S)-Hydroxydecanoyl-CoA <=> trans-Dec-2-enoyl-CoA + H2O

(S)-hydroxydecanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04746

(S)-3-Hydroxyoctanoyl-CoA <=> trans-Oct-2-enoyl-CoA + H2O

(S)-hydroxyoctanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R04749

(S)-Hydroxyhexanoyl-CoA <=> trans-Hex-2-enoyl-CoA + H2O

(S)-hydroxyhexanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R05595

Crotonoyl-CoA + H2O <=> 3-Hydroxybutanoyl-CoA

Swm_00449 K01692 paaF, echA R06411

cis-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06412

trans-2-Methyl-5-isopropylhexa-2,5-dienoyl-CoA + H2O <=> 3-Hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA

trans-2-methyl-5-isopropylhexa-2,5-dienoyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R06942

5-Carboxy-2-pentenoyl-CoA + H2O <=> (3S)-3-Hydroxyadipyl-CoA

(3S)-3-hydroxyacyl-CoA hydro-lyase

Swm_00449 K01692 paaF, echA R08093

(2E)-5-Methylhexa-2,4-dienoyl-CoA + H2O <=> 3-Hydroxy-5-methylhex-4-enoyl-CoA

3-hydroxy-5-methylhex-4-enoyl-CoA hydro-lyase

Pathway 000721 genes · 2 rxns

Swm_00450 K00626 ACAT, atoB R00238

2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA

acetyl-CoA:acetyl-CoA C-acetyltransferase

Swm_00450 K00626 ACAT, atoB R01177

Acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA

butanoyl-CoA:acetyl-CoA C-butanoyltransferase

Pyruvate metabolismMetabolism; Carbohydrate metabolism1 genes · 2 rxns

Swm_00450 K00626 ACAT, atoB R00238

2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA

acetyl-CoA:acetyl-CoA C-acetyltransferase

Swm_00450 K00626 ACAT, atoB R01177

Acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA

butanoyl-CoA:acetyl-CoA C-butanoyltransferase

Glyoxylate and dicarboxylate metabolismMetabolism; Carbohydrate metabolism1 genes · 2 rxns

Swm_00450 K00626 ACAT, atoB R00238

2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA

acetyl-CoA:acetyl-CoA C-acetyltransferase

Swm_00450 K00626 ACAT, atoB R01177

Acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA

butanoyl-CoA:acetyl-CoA C-butanoyltransferase

Other carbon fixation pathwaysMetabolism; Energy metabolism1 genes · 2 rxns

Swm_00450 K00626 ACAT, atoB R00238

2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA

acetyl-CoA:acetyl-CoA C-acetyltransferase

Swm_00450 K00626 ACAT, atoB R01177

Acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA

butanoyl-CoA:acetyl-CoA C-butanoyltransferase

Terpenoid backbone biosynthesisMetabolism; Metabolism of terpenoids and polyketides1 genes · 2 rxns

Swm_00450 K00626 ACAT, atoB R00238

2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA

acetyl-CoA:acetyl-CoA C-acetyltransferase

Swm_00450 K00626 ACAT, atoB R01177

Acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA

butanoyl-CoA:acetyl-CoA C-butanoyltransferase

Two-component systemEnvironmental Information Processing; Signal transduction1 genes · 2 rxns

Swm_00450 K00626 ACAT, atoB R00238

2 Acetyl-CoA <=> CoA + Acetoacetyl-CoA

acetyl-CoA:acetyl-CoA C-acetyltransferase

Swm_00450 K00626 ACAT, atoB R01177

Acetyl-CoA + Butanoyl-CoA <=> CoA + 3-Oxohexanoyl-CoA

butanoyl-CoA:acetyl-CoA C-butanoyltransferase

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 4 genes

Swm_00448 Swm_00449 Swm_00450 Swm_00451

Microbial metabolism in diverse environments 4 genes

Swm_00448 Swm_00449 Swm_00450 Swm_00451

Fatty acid metabolism 3 genes

Swm_00449 Swm_00450 Swm_00451

Carbon metabolism 3 genes

Swm_00449 Swm_00450 Swm_00451

Biosynthesis of secondary metabolites 3 genes

Swm_00449 Swm_00450 Swm_00451

Map 01130 2 genes

Swm_00449 Swm_00450

Reaction network — compounds linked by the reactions these genes catalyse

show cofactors (H₂O, ATP, NAD⁺…) drag nodes · click an edge for the reaction

Genes

Locus	Product	KO	EC	Reactions
Swm_00448	3-hydroxyacyl-CoA dehydrogenase family protein	K00074 paaH, hbd, fadB, mmgB	1.1.1.157	R01976,R05576,R06941
Swm_00449	enoyl-CoA hydratase/isomerase family protein	K01692 paaF, echA; K01715 crt	4.2.1.17	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093
Swm_00450	thiolase family protein	K00626 ACAT, atoB	2.3.1.9	R00238,R01177
Swm_00451	acyl-CoA dehydrogenase family protein	K00248 ACADS, bcd	1.3.8.1	R01175,R01178,R02661,R03172,R04751

Small Microbes Pathway Profiler

Operon NZ_CM161534.1:519,194–523,416

Activity by pathway — click to expand; ranked by genes involved

Overview / global maps (every metabolic gene maps here)

Reaction network — compounds linked by the reactions these genes catalyse

Genes