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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_CM161534.1:735,896–739,222

Syntrophomonas wolfei methylbutyratica 4J5 · 3 genes
3
genes
3
KO-annotated
7
reactions
11
pathways

Activity by pathway — click to expand; ranked by genes involved

Amino sugar and nucleotide sugar metabolismMetabolism; Glycan biosynthesis and metabolism3 genes · 7 rxns
Swm_00651 K00012 UGDH, ugd R00286
UDP-glucose + H2O + 2 NAD+ <=> UDP-glucuronate + 2 NADH + 2 H+
UDP-glucose:NAD+ 6-oxidoreductase
Swm_00651 K00012 UGDH, ugd R00880
GDP-mannose + H2O + 2 NAD+ <=> GDP-D-mannuronate + 2 NADH + 2 H+
GDP-D-mannose:NAD+ 6-oxidoreductase
Swm_00651 K00012 UGDH, ugd R03317
UDP-N-acetyl-D-mannosamine + 2 NAD+ + H2O <=> UDP-N-acetyl-D-mannosaminouronate + 2 NADH + 2 H+
UDP-N-acetyl-alpha-D-mannosamine:NAD+ 6-oxidoreductase
Swm_00652 K01710 rfbB, rmlB, rffG R00291
UDP-glucose <=> UDP-alpha-D-galactose
UDP-glucose 4-epimerase; UDP-alpha-D-glucose 4-epimerase
Swm_00652 K01710 rfbB, rmlB, rffG R02984
dTDP-glucose <=> dTDP-galactose
dTDPglucose 4-epimerase
Swm_00652 K01710 rfbB, rmlB, rffG R06513
dTDP-glucose <=> dTDP-4-oxo-6-deoxy-D-glucose + H2O
dTDPglucose 4,6-hydro-lyase
Swm_00653 K02377 TSTA3, fcl R05692
GDP-L-fucose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+
GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)
Fructose and mannose metabolismMetabolism; Carbohydrate metabolism2 genes · 4 rxns
Swm_00651 K00012 UGDH, ugd R00286
UDP-glucose + H2O + 2 NAD+ <=> UDP-glucuronate + 2 NADH + 2 H+
UDP-glucose:NAD+ 6-oxidoreductase
Swm_00651 K00012 UGDH, ugd R00880
GDP-mannose + H2O + 2 NAD+ <=> GDP-D-mannuronate + 2 NADH + 2 H+
GDP-D-mannose:NAD+ 6-oxidoreductase
Swm_00651 K00012 UGDH, ugd R03317
UDP-N-acetyl-D-mannosamine + 2 NAD+ + H2O <=> UDP-N-acetyl-D-mannosaminouronate + 2 NADH + 2 H+
UDP-N-acetyl-alpha-D-mannosamine:NAD+ 6-oxidoreductase
Swm_00653 K02377 TSTA3, fcl R05692
GDP-L-fucose + NADP+ <=> GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+
GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing)
Pentose and glucuronate interconversionsMetabolism; Carbohydrate metabolism1 genes · 3 rxns
Swm_00651 K00012 UGDH, ugd R00286
UDP-glucose + H2O + 2 NAD+ <=> UDP-glucuronate + 2 NADH + 2 H+
UDP-glucose:NAD+ 6-oxidoreductase
Swm_00651 K00012 UGDH, ugd R00880
GDP-mannose + H2O + 2 NAD+ <=> GDP-D-mannuronate + 2 NADH + 2 H+
GDP-D-mannose:NAD+ 6-oxidoreductase
Swm_00651 K00012 UGDH, ugd R03317
UDP-N-acetyl-D-mannosamine + 2 NAD+ + H2O <=> UDP-N-acetyl-D-mannosaminouronate + 2 NADH + 2 H+
UDP-N-acetyl-alpha-D-mannosamine:NAD+ 6-oxidoreductase
Ascorbate and aldarate metabolismMetabolism; Carbohydrate metabolism1 genes · 3 rxns
Swm_00651 K00012 UGDH, ugd R00286
UDP-glucose + H2O + 2 NAD+ <=> UDP-glucuronate + 2 NADH + 2 H+
UDP-glucose:NAD+ 6-oxidoreductase
Swm_00651 K00012 UGDH, ugd R00880
GDP-mannose + H2O + 2 NAD+ <=> GDP-D-mannuronate + 2 NADH + 2 H+
GDP-D-mannose:NAD+ 6-oxidoreductase
Swm_00651 K00012 UGDH, ugd R03317
UDP-N-acetyl-D-mannosamine + 2 NAD+ + H2O <=> UDP-N-acetyl-D-mannosaminouronate + 2 NADH + 2 H+
UDP-N-acetyl-alpha-D-mannosamine:NAD+ 6-oxidoreductase
Two-component systemEnvironmental Information Processing; Signal transduction1 genes · 3 rxns
Swm_00651 K00012 UGDH, ugd R00286
UDP-glucose + H2O + 2 NAD+ <=> UDP-glucuronate + 2 NADH + 2 H+
UDP-glucose:NAD+ 6-oxidoreductase
Swm_00651 K00012 UGDH, ugd R00880
GDP-mannose + H2O + 2 NAD+ <=> GDP-D-mannuronate + 2 NADH + 2 H+
GDP-D-mannose:NAD+ 6-oxidoreductase
Swm_00651 K00012 UGDH, ugd R03317
UDP-N-acetyl-D-mannosamine + 2 NAD+ + H2O <=> UDP-N-acetyl-D-mannosaminouronate + 2 NADH + 2 H+
UDP-N-acetyl-alpha-D-mannosamine:NAD+ 6-oxidoreductase
Biofilm formation - Vibrio choleraeCellular Processes; Cellular community - prokaryotes1 genes · 3 rxns
Swm_00651 K00012 UGDH, ugd R00286
UDP-glucose + H2O + 2 NAD+ <=> UDP-glucuronate + 2 NADH + 2 H+
UDP-glucose:NAD+ 6-oxidoreductase
Swm_00651 K00012 UGDH, ugd R00880
GDP-mannose + H2O + 2 NAD+ <=> GDP-D-mannuronate + 2 NADH + 2 H+
GDP-D-mannose:NAD+ 6-oxidoreductase
Swm_00651 K00012 UGDH, ugd R03317
UDP-N-acetyl-D-mannosamine + 2 NAD+ + H2O <=> UDP-N-acetyl-D-mannosaminouronate + 2 NADH + 2 H+
UDP-N-acetyl-alpha-D-mannosamine:NAD+ 6-oxidoreductase
Galactose metabolismMetabolism; Carbohydrate metabolism1 genes · 3 rxns
Swm_00652 K01710 rfbB, rmlB, rffG R00291
UDP-glucose <=> UDP-alpha-D-galactose
UDP-glucose 4-epimerase; UDP-alpha-D-glucose 4-epimerase
Swm_00652 K01710 rfbB, rmlB, rffG R02984
dTDP-glucose <=> dTDP-galactose
dTDPglucose 4-epimerase
Swm_00652 K01710 rfbB, rmlB, rffG R06513
dTDP-glucose <=> dTDP-4-oxo-6-deoxy-D-glucose + H2O
dTDPglucose 4,6-hydro-lyase
Streptomycin biosynthesisMetabolism; Biosynthesis of other secondary metabolites1 genes · 3 rxns
Swm_00652 K01710 rfbB, rmlB, rffG R00291
UDP-glucose <=> UDP-alpha-D-galactose
UDP-glucose 4-epimerase; UDP-alpha-D-glucose 4-epimerase
Swm_00652 K01710 rfbB, rmlB, rffG R02984
dTDP-glucose <=> dTDP-galactose
dTDPglucose 4-epimerase
Swm_00652 K01710 rfbB, rmlB, rffG R06513
dTDP-glucose <=> dTDP-4-oxo-6-deoxy-D-glucose + H2O
dTDPglucose 4,6-hydro-lyase
Polyketide sugar unit biosynthesisMetabolism; Metabolism of terpenoids and polyketides1 genes · 3 rxns
Swm_00652 K01710 rfbB, rmlB, rffG R00291
UDP-glucose <=> UDP-alpha-D-galactose
UDP-glucose 4-epimerase; UDP-alpha-D-glucose 4-epimerase
Swm_00652 K01710 rfbB, rmlB, rffG R02984
dTDP-glucose <=> dTDP-galactose
dTDPglucose 4-epimerase
Swm_00652 K01710 rfbB, rmlB, rffG R06513
dTDP-glucose <=> dTDP-4-oxo-6-deoxy-D-glucose + H2O
dTDPglucose 4,6-hydro-lyase
Acarbose and validamycin biosynthesisMetabolism; Biosynthesis of other secondary metabolites1 genes · 3 rxns
Swm_00652 K01710 rfbB, rmlB, rffG R00291
UDP-glucose <=> UDP-alpha-D-galactose
UDP-glucose 4-epimerase; UDP-alpha-D-glucose 4-epimerase
Swm_00652 K01710 rfbB, rmlB, rffG R02984
dTDP-glucose <=> dTDP-galactose
dTDPglucose 4-epimerase
Swm_00652 K01710 rfbB, rmlB, rffG R06513
dTDP-glucose <=> dTDP-4-oxo-6-deoxy-D-glucose + H2O
dTDPglucose 4,6-hydro-lyase
Biosynthesis of vancomycin group antibioticsMetabolism; Metabolism of terpenoids and polyketides1 genes · 3 rxns
Swm_00652 K01710 rfbB, rmlB, rffG R00291
UDP-glucose <=> UDP-alpha-D-galactose
UDP-glucose 4-epimerase; UDP-alpha-D-glucose 4-epimerase
Swm_00652 K01710 rfbB, rmlB, rffG R02984
dTDP-glucose <=> dTDP-galactose
dTDPglucose 4-epimerase
Swm_00652 K01710 rfbB, rmlB, rffG R06513
dTDP-glucose <=> dTDP-4-oxo-6-deoxy-D-glucose + H2O
dTDPglucose 4,6-hydro-lyase

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 3 genes
Swm_00651 Swm_00652 Swm_00653
Map 01130 1 genes
Swm_00652

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Swm_00651 nucleotide sugar dehydrogenase K00012 UGDH, ugd; K00066 algD; K02472 wecC 1.1.1.132,1.1.1.22,1.1.1.336 R00286,R00880,R03317
Swm_00652 NAD-dependent epimerase/dehydratase family protein K01710 rfbB, rmlB, rffG; K01784 galE, GALE 4.2.1.46,5.1.3.2 R00291,R02984,R06513
Swm_00653 GDP-L-fucose synthase family protein K02377 TSTA3, fcl 1.1.1.271 R05692
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