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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_CM161534.1:758,467–762,687

Syntrophomonas wolfei methylbutyratica 4J5 · 5 genes
5
genes
3
KO-annotated
9
reactions
2
pathways

Activity by pathway — click to expand; ranked by genes involved

Thiamine metabolismMetabolism; Metabolism of cofactors and vitamins3 genes · 9 rxns
Swm_00673 K00868 pdxK, pdxY R00174
ATP + Pyridoxal <=> ADP + Pyridoxal phosphate
ATP:pyridoxal 5'-phosphotransferase
Swm_00673 K00868 pdxK, pdxY R01909
ATP + Pyridoxine <=> ADP + Pyridoxine phosphate
ATP:pyridoxine 5'-phosphotransferase
Swm_00673 K00868 pdxK, pdxY R02493
ATP + Pyridoxamine <=> ADP + Pyridoxamine phosphate
ATP:pyridoxal 5'-phosphotransferase
Swm_00673 K00868 pdxK, pdxY R03223
4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate + 4-Methyl-5-(2-phosphooxyethyl)thiazole <=> Diphosphate + Thiamin monophosphate
2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)-thiazole 2-methyl-4-aminopyridine-5-methenyltransferase
Swm_00673 K00868 pdxK, pdxY R03471
ATP + 4-Amino-5-hydroxymethyl-2-methylpyrimidine <=> ADP + 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase
Swm_00673 K00868 pdxK, pdxY R04509
ATP + 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine <=> ADP + 4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase
Swm_00673 K00868 pdxK, pdxY R10712
4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate + 2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate <=> Thiamin monophosphate + Diphosphate + CO2
2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate 2-methyl-4-aminopyrimidine-5-methenyltransferase
Swm_00674 K00878 thiM R04448
ATP + 5-(2-Hydroxyethyl)-4-methylthiazole <=> ADP + 4-Methyl-5-(2-phosphooxyethyl)thiazole
ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase
Swm_00677 K03147 thiC R03472
Aminoimidazole ribotide + S-Adenosyl-L-methionine <=> 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-Deoxyadenosine + L-Methionine + Formate + CO
5-amino-1-(5-phospho-D-ribosyl)imidazole formate-lyase (decarboxylating, 4-amino-2-methyl-5-phosphomethylpyrimidine-forming)
Vitamin B6 metabolismMetabolism; Metabolism of cofactors and vitamins1 genes · 7 rxns
Swm_00673 K00868 pdxK, pdxY R00174
ATP + Pyridoxal <=> ADP + Pyridoxal phosphate
ATP:pyridoxal 5'-phosphotransferase
Swm_00673 K00868 pdxK, pdxY R01909
ATP + Pyridoxine <=> ADP + Pyridoxine phosphate
ATP:pyridoxine 5'-phosphotransferase
Swm_00673 K00868 pdxK, pdxY R02493
ATP + Pyridoxamine <=> ADP + Pyridoxamine phosphate
ATP:pyridoxal 5'-phosphotransferase
Swm_00673 K00868 pdxK, pdxY R03223
4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate + 4-Methyl-5-(2-phosphooxyethyl)thiazole <=> Diphosphate + Thiamin monophosphate
2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)-thiazole 2-methyl-4-aminopyridine-5-methenyltransferase
Swm_00673 K00868 pdxK, pdxY R03471
ATP + 4-Amino-5-hydroxymethyl-2-methylpyrimidine <=> ADP + 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine
ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase
Swm_00673 K00868 pdxK, pdxY R04509
ATP + 4-Amino-2-methyl-5-(phosphooxymethyl)pyrimidine <=> ADP + 4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate
ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase
Swm_00673 K00868 pdxK, pdxY R10712
4-Amino-5-hydroxymethyl-2-methylpyrimidine diphosphate + 2-(2-Carboxy-4-methylthiazol-5-yl)ethyl phosphate <=> Thiamin monophosphate + Diphosphate + CO2
2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate 2-methyl-4-aminopyrimidine-5-methenyltransferase

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 3 genes
Swm_00673 Swm_00674 Swm_00677

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Swm_00673 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase K00868 pdxK, pdxY; K00941 thiD; K14153 thiDE 2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7 R00174,R01909,R02493,R03223,R03471,R04509,R10712
Swm_00674 hydroxyethylthiazole kinase K00878 thiM 2.7.1.50 R04448
Swm_00675 thiamine phosphate synthase — — —
Swm_00676 MtnX-like HAD-IB family phosphatase — — —
Swm_00677 phosphomethylpyrimidine synthase ThiC K03147 thiC 4.1.99.17 R03472
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