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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_CM161534.1:1,122,470–1,125,606

Syntrophomonas wolfei methylbutyratica 4J5 · 2 genes
2
genes
2
KO-annotated
4
reactions
5
pathways

Activity by pathway — click to expand; ranked by genes involved

Cysteine and methionine metabolismMetabolism; Amino acid metabolism1 genes · 2 rxns
Swm_01014 K00549 metE R04405
5-Methyltetrahydropteroyltri-L-glutamate + L-Homocysteine <=> Tetrahydropteroyltri-L-glutamate + L-Methionine
5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase
Swm_01014 K00549 metE R09365
Selenohomocysteine + 5-Methyltetrahydropteroyltri-L-glutamate <=> L-Selenomethionine + Tetrahydropteroyltri-L-glutamate
5-methyltetrahydropteroyltri-L-glutamate:L-selenohomocysteine Se-methyltransferase
Selenocompound metabolismMetabolism; Metabolism of other amino acids1 genes · 2 rxns
Swm_01014 K00549 metE R04405
5-Methyltetrahydropteroyltri-L-glutamate + L-Homocysteine <=> Tetrahydropteroyltri-L-glutamate + L-Methionine
5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase
Swm_01014 K00549 metE R09365
Selenohomocysteine + 5-Methyltetrahydropteroyltri-L-glutamate <=> L-Selenomethionine + Tetrahydropteroyltri-L-glutamate
5-methyltetrahydropteroyltri-L-glutamate:L-selenohomocysteine Se-methyltransferase
One carbon pool by folateMetabolism; Metabolism of cofactors and vitamins1 genes · 2 rxns
Swm_01015 K00297 metF, MTHFR R01224
5-Methyltetrahydrofolate + NADP+ <=> 5,10-Methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate:NADP+ oxidoreductase
Swm_01015 K00297 metF, MTHFR R07168
5-Methyltetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate:NAD+ oxidoreductase
Other carbon fixation pathwaysMetabolism; Energy metabolism1 genes · 2 rxns
Swm_01015 K00297 metF, MTHFR R01224
5-Methyltetrahydrofolate + NADP+ <=> 5,10-Methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate:NADP+ oxidoreductase
Swm_01015 K00297 metF, MTHFR R07168
5-Methyltetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate:NAD+ oxidoreductase
Antifolate resistanceHuman Diseases; Drug resistance: antineoplastic1 genes · 2 rxns
Swm_01015 K00297 metF, MTHFR R01224
5-Methyltetrahydrofolate + NADP+ <=> 5,10-Methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate:NADP+ oxidoreductase
Swm_01015 K00297 metF, MTHFR R07168
5-Methyltetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate:NAD+ oxidoreductase

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 2 genes
Swm_01014 Swm_01015
Biosynthesis of secondary metabolites 1 genes
Swm_01014
Biosynthesis of amino acids 1 genes
Swm_01014
Microbial metabolism in diverse environments 1 genes
Swm_01015
Carbon metabolism 1 genes
Swm_01015

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Swm_01014 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase K00549 metE 2.1.1.14 R04405,R09365
Swm_01015 methylenetetrahydrofolate reductase [NAD(P)H] K00297 metF, MTHFR 1.5.1.20 R01224,R07168
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