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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_CM161534.1:2,518,916–2,521,328

Syntrophomonas wolfei methylbutyratica 4J5 · 2 genes
2
genes
2
KO-annotated
9
reactions
8
pathways

Activity by pathway — click to expand; ranked by genes involved

Lipoic acid metabolismMetabolism; Metabolism of cofactors and vitamins1 genes · 3 rxns
Swm_02287 K03800 lplA, lplJ, lipL1 R07770
ATP + (R)-Lipoate <=> Diphosphate + Lipoyl-AMP
Swm_02287 K03800 lplA, lplJ, lipL1 R07771
Lipoyl-AMP + [Lipoyl-carrier protein]-L-lysine <=> Protein N6-(lipoyl)lysine + AMP
Swm_02287 K03800 lplA, lplJ, lipL1 R11143
ATP + (R)-Lipoate + [Lipoyl-carrier protein]-L-lysine <=> Protein N6-(lipoyl)lysine + AMP + Diphosphate
[lipoyl-carrier protein]-L-lysine:lipoate ligase (AMP-forming)
Glycolysis / GluconeogenesisMetabolism; Carbohydrate metabolism1 genes · 6 rxns
Swm_02288 K00382 DLD, lpd, pdhD R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Swm_02288 K00382 DLD, lpd, pdhD R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Swm_02288 K00382 DLD, lpd, pdhD R01698
Dihydrolipoamide + NAD+ <=> Lipoamide + NADH + H+
dihydrolipoamide:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R03815
Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+
dihydrolipoylprotein:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R07618
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R08549
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating); 2-oxoglutarate dehydrogenase complex
Citrate cycle (TCA cycle)Metabolism; Carbohydrate metabolism1 genes · 6 rxns
Swm_02288 K00382 DLD, lpd, pdhD R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Swm_02288 K00382 DLD, lpd, pdhD R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Swm_02288 K00382 DLD, lpd, pdhD R01698
Dihydrolipoamide + NAD+ <=> Lipoamide + NADH + H+
dihydrolipoamide:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R03815
Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+
dihydrolipoylprotein:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R07618
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R08549
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating); 2-oxoglutarate dehydrogenase complex
Glycine, serine and threonine metabolismMetabolism; Amino acid metabolism1 genes · 6 rxns
Swm_02288 K00382 DLD, lpd, pdhD R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Swm_02288 K00382 DLD, lpd, pdhD R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Swm_02288 K00382 DLD, lpd, pdhD R01698
Dihydrolipoamide + NAD+ <=> Lipoamide + NADH + H+
dihydrolipoamide:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R03815
Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+
dihydrolipoylprotein:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R07618
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R08549
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating); 2-oxoglutarate dehydrogenase complex
Valine, leucine and isoleucine degradationMetabolism; Amino acid metabolism1 genes · 6 rxns
Swm_02288 K00382 DLD, lpd, pdhD R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Swm_02288 K00382 DLD, lpd, pdhD R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Swm_02288 K00382 DLD, lpd, pdhD R01698
Dihydrolipoamide + NAD+ <=> Lipoamide + NADH + H+
dihydrolipoamide:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R03815
Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+
dihydrolipoylprotein:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R07618
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R08549
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating); 2-oxoglutarate dehydrogenase complex
Pyruvate metabolismMetabolism; Carbohydrate metabolism1 genes · 6 rxns
Swm_02288 K00382 DLD, lpd, pdhD R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Swm_02288 K00382 DLD, lpd, pdhD R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Swm_02288 K00382 DLD, lpd, pdhD R01698
Dihydrolipoamide + NAD+ <=> Lipoamide + NADH + H+
dihydrolipoamide:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R03815
Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+
dihydrolipoylprotein:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R07618
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R08549
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating); 2-oxoglutarate dehydrogenase complex
Glyoxylate and dicarboxylate metabolismMetabolism; Carbohydrate metabolism1 genes · 6 rxns
Swm_02288 K00382 DLD, lpd, pdhD R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Swm_02288 K00382 DLD, lpd, pdhD R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Swm_02288 K00382 DLD, lpd, pdhD R01698
Dihydrolipoamide + NAD+ <=> Lipoamide + NADH + H+
dihydrolipoamide:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R03815
Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+
dihydrolipoylprotein:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R07618
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R08549
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating); 2-oxoglutarate dehydrogenase complex
Propanoate metabolismMetabolism; Carbohydrate metabolism1 genes · 6 rxns
Swm_02288 K00382 DLD, lpd, pdhD R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Swm_02288 K00382 DLD, lpd, pdhD R01221
Glycine + Tetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + Ammonia + CO2 + NADH + H+
glycine:NAD+ 2-oxidoreductase (tetrahydrofolate-methylene-adding); glycine cleavage system
Swm_02288 K00382 DLD, lpd, pdhD R01698
Dihydrolipoamide + NAD+ <=> Lipoamide + NADH + H+
dihydrolipoamide:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R03815
Dihydrolipoylprotein + NAD+ <=> Lipoylprotein + NADH + H+
dihydrolipoylprotein:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R07618
Enzyme N6-(dihydrolipoyl)lysine + NAD+ <=> Enzyme N6-(lipoyl)lysine + NADH + H+
enzyme N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase
Swm_02288 K00382 DLD, lpd, pdhD R08549
2-Oxoglutarate + CoA + NAD+ <=> Succinyl-CoA + CO2 + NADH + H+
2-oxoglutarate:NAD+ 2-oxidoreductase (CoA-succinylating); 2-oxoglutarate dehydrogenase complex

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 2 genes
Swm_02287 Swm_02288
Biosynthesis of secondary metabolites 1 genes
Swm_02288
Microbial metabolism in diverse environments 1 genes
Swm_02288
Map 01130 1 genes
Swm_02288
Carbon metabolism 1 genes
Swm_02288

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Swm_02287 lipoate--protein ligase K03800 lplA, lplJ, lipL1 6.3.1.20 R07770,R07771,R11143
Swm_02288 dihydrolipoyl dehydrogenase K00382 DLD, lpd, pdhD 1.8.1.4 R00209,R01221,R01698,R03815,R07618,R08549
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