Small Microbes Pathway Profiler

Domain Counts
Profiler Search and BLAST
CAZy ▾
CAZyme Browser CAzy - DBCAN (original) CAZyme protein counts Proteome Coverage Summary
Search ▾
Text search Domain display search
Pathways ▾
Nitrogen Fixation CANT-Hyd
UMAP
◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_CM161534.1:2,822,041–2,825,361

Syntrophomonas wolfei methylbutyratica 4J5 · 3 genes
3
genes
3
KO-annotated
12
reactions
4
pathways

Activity by pathway — click to expand; ranked by genes involved

Valine, leucine and isoleucine biosynthesisMetabolism; Amino acid metabolism3 genes · 17 rxns
Swm_02559 K01704 leuD, IPMI-S R03896
(R)-2-Methylmalate <=> 2-Methylmaleate + H2O
(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_02559 K01704 leuD, IPMI-S R03898
2-Methylmaleate + H2O <=> D-erythro-3-Methylmalate
2-methylmaleate hydratase; D-erythro-3-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_02559 K01704 leuD, IPMI-S R03968
alpha-Isopropylmalate <=> 2-Isopropylmaleate + H2O
2-isopropylmalate hydro-lyase
Swm_02559 K01704 leuD, IPMI-S R04001
(2R,3S)-3-Isopropylmalate <=> 2-Isopropylmaleate + H2O
3-isopropylmalate hydro-lyase
Swm_02559 K01704 leuD, IPMI-S R10170
(2R,3S)-3-Isopropylmalate <=> alpha-Isopropylmalate
(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
Swm_02560 K01703 leuC, IPMI-L R03896
(R)-2-Methylmalate <=> 2-Methylmaleate + H2O
(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_02560 K01703 leuC, IPMI-L R03898
2-Methylmaleate + H2O <=> D-erythro-3-Methylmalate
2-methylmaleate hydratase; D-erythro-3-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_02560 K01703 leuC, IPMI-L R03968
alpha-Isopropylmalate <=> 2-Isopropylmaleate + H2O
2-isopropylmalate hydro-lyase
Swm_02560 K01703 leuC, IPMI-L R04001
(2R,3S)-3-Isopropylmalate <=> 2-Isopropylmaleate + H2O
3-isopropylmalate hydro-lyase
Swm_02560 K01703 leuC, IPMI-L R08620
2-(2'-Methylthio)ethylmalic acid <=> 3-(2'-Methylthio)ethylmalic acid
2-(2'-methylthio)ethylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R08624
2-(3'-Methylthio)propylmalic acid <=> 3-(3'-Methylthio)propylmalic acid
2-(3'-methylthio)propylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R08628
2-(4'-Methylthio)butylmalic acid <=> 3-(4'-Methylthio)butylmalic acid
2-(3'-methylthio)butylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R08634
2-(5'-Methylthio)pentylmalic acid <=> 3-(5'-Methylthio)pentylmalic acid
2-(3'-methylthio)pentylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R08641
2-(6'-Methylthio)hexylmalic acid <=> 3-(6'-Methylthio)hexylmalic acid
2-(3'-methylthio)hexylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R08645
2-(7'-Methylthio)heptylmalic acid <=> 3-(7'-Methylthio)heptylmalic acid
2-(3'-methylthio)heptylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R10170
(2R,3S)-3-Isopropylmalate <=> alpha-Isopropylmalate
(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
Swm_02561 K01649 leuA, IMS R01213
alpha-Isopropylmalate + CoA <=> Acetyl-CoA + 3-Methyl-2-oxobutanoic acid + H2O
acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming); 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)
C5-Branched dibasic acid metabolismMetabolism; Carbohydrate metabolism2 genes · 16 rxns
Swm_02559 K01704 leuD, IPMI-S R03896
(R)-2-Methylmalate <=> 2-Methylmaleate + H2O
(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_02559 K01704 leuD, IPMI-S R03898
2-Methylmaleate + H2O <=> D-erythro-3-Methylmalate
2-methylmaleate hydratase; D-erythro-3-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_02559 K01704 leuD, IPMI-S R03968
alpha-Isopropylmalate <=> 2-Isopropylmaleate + H2O
2-isopropylmalate hydro-lyase
Swm_02559 K01704 leuD, IPMI-S R04001
(2R,3S)-3-Isopropylmalate <=> 2-Isopropylmaleate + H2O
3-isopropylmalate hydro-lyase
Swm_02559 K01704 leuD, IPMI-S R10170
(2R,3S)-3-Isopropylmalate <=> alpha-Isopropylmalate
(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
Swm_02560 K01703 leuC, IPMI-L R03896
(R)-2-Methylmalate <=> 2-Methylmaleate + H2O
(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_02560 K01703 leuC, IPMI-L R03898
2-Methylmaleate + H2O <=> D-erythro-3-Methylmalate
2-methylmaleate hydratase; D-erythro-3-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_02560 K01703 leuC, IPMI-L R03968
alpha-Isopropylmalate <=> 2-Isopropylmaleate + H2O
2-isopropylmalate hydro-lyase
Swm_02560 K01703 leuC, IPMI-L R04001
(2R,3S)-3-Isopropylmalate <=> 2-Isopropylmaleate + H2O
3-isopropylmalate hydro-lyase
Swm_02560 K01703 leuC, IPMI-L R08620
2-(2'-Methylthio)ethylmalic acid <=> 3-(2'-Methylthio)ethylmalic acid
2-(2'-methylthio)ethylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R08624
2-(3'-Methylthio)propylmalic acid <=> 3-(3'-Methylthio)propylmalic acid
2-(3'-methylthio)propylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R08628
2-(4'-Methylthio)butylmalic acid <=> 3-(4'-Methylthio)butylmalic acid
2-(3'-methylthio)butylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R08634
2-(5'-Methylthio)pentylmalic acid <=> 3-(5'-Methylthio)pentylmalic acid
2-(3'-methylthio)pentylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R08641
2-(6'-Methylthio)hexylmalic acid <=> 3-(6'-Methylthio)hexylmalic acid
2-(3'-methylthio)hexylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R08645
2-(7'-Methylthio)heptylmalic acid <=> 3-(7'-Methylthio)heptylmalic acid
2-(3'-methylthio)heptylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R10170
(2R,3S)-3-Isopropylmalate <=> alpha-Isopropylmalate
(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
Glucosinolate biosynthesisMetabolism; Biosynthesis of other secondary metabolites1 genes · 11 rxns
Swm_02560 K01703 leuC, IPMI-L R03896
(R)-2-Methylmalate <=> 2-Methylmaleate + H2O
(R)-2-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_02560 K01703 leuC, IPMI-L R03898
2-Methylmaleate + H2O <=> D-erythro-3-Methylmalate
2-methylmaleate hydratase; D-erythro-3-methylmalate hydro-lyase (2-methylmaleate-forming)
Swm_02560 K01703 leuC, IPMI-L R03968
alpha-Isopropylmalate <=> 2-Isopropylmaleate + H2O
2-isopropylmalate hydro-lyase
Swm_02560 K01703 leuC, IPMI-L R04001
(2R,3S)-3-Isopropylmalate <=> 2-Isopropylmaleate + H2O
3-isopropylmalate hydro-lyase
Swm_02560 K01703 leuC, IPMI-L R08620
2-(2'-Methylthio)ethylmalic acid <=> 3-(2'-Methylthio)ethylmalic acid
2-(2'-methylthio)ethylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R08624
2-(3'-Methylthio)propylmalic acid <=> 3-(3'-Methylthio)propylmalic acid
2-(3'-methylthio)propylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R08628
2-(4'-Methylthio)butylmalic acid <=> 3-(4'-Methylthio)butylmalic acid
2-(3'-methylthio)butylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R08634
2-(5'-Methylthio)pentylmalic acid <=> 3-(5'-Methylthio)pentylmalic acid
2-(3'-methylthio)pentylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R08641
2-(6'-Methylthio)hexylmalic acid <=> 3-(6'-Methylthio)hexylmalic acid
2-(3'-methylthio)hexylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R08645
2-(7'-Methylthio)heptylmalic acid <=> 3-(7'-Methylthio)heptylmalic acid
2-(3'-methylthio)heptylmalate hydroxymutase
Swm_02560 K01703 leuC, IPMI-L R10170
(2R,3S)-3-Isopropylmalate <=> alpha-Isopropylmalate
(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)
Pyruvate metabolismMetabolism; Carbohydrate metabolism1 genes · 1 rxns
Swm_02561 K01649 leuA, IMS R01213
alpha-Isopropylmalate + CoA <=> Acetyl-CoA + 3-Methyl-2-oxobutanoic acid + H2O
acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming); 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating)

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 3 genes
Swm_02559 Swm_02560 Swm_02561
Biosynthesis of secondary metabolites 3 genes
Swm_02559 Swm_02560 Swm_02561
2-Oxocarboxylic acid metabolism 3 genes
Swm_02559 Swm_02560 Swm_02561
Biosynthesis of amino acids 3 genes
Swm_02559 Swm_02560 Swm_02561

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Swm_02559 3-isopropylmalate dehydratase small subunit K01704 leuD, IPMI-S 4.2.1.33,4.2.1.35 R03896,R03898,R03968,R04001,R10170
Swm_02560 3-isopropylmalate dehydratase large subunit K01703 leuC, IPMI-L 4.2.1.33,4.2.1.35 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170
Swm_02561 2-isopropylmalate synthase K01649 leuA, IMS 2.3.3.13 R01213
↑ Top




v1.00 @copyright 2026 UCLA