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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_CM161534.1:3,026,560–3,030,390

Syntrophomonas wolfei methylbutyratica 4J5 · 4 genes
4
genes
2
KO-annotated
8
reactions
4
pathways

Activity by pathway — click to expand; ranked by genes involved

One carbon pool by folateMetabolism; Metabolism of cofactors and vitamins2 genes · 8 rxns
Swm_02760 K00287 DHFR, folA R00936
Tetrahydrofolate + NAD+ <=> Dihydrofolate + NADH + H+
5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
Swm_02760 K00287 DHFR, folA R00937
Tetrahydrofolate + 2 NAD+ <=> Folate + 2 NADH + 2 H+
5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
Swm_02760 K00287 DHFR, folA R00939
Tetrahydrofolate + NADP+ <=> Dihydrofolate + NADPH + H+
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
Swm_02760 K00287 DHFR, folA R00940
Tetrahydrofolate + 2 NADP+ <=> Folate + 2 NADPH + 2 H+
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
Swm_02760 K00287 DHFR, folA R02235
Dihydrofolate + NAD+ <=> Folate + NADH + H+
dihydrofolate:NAD+ oxidoreductase
Swm_02760 K00287 DHFR, folA R02236
Dihydrofolate + NADP+ <=> Folate + NADPH + H+
dihydrofolate:NADP+ oxidoreductase
Swm_02760 K00287 DHFR, folA R11765
Tetrahydrobiopterin + NADP+ <=> 7,8-Dihydrobiopterin + NADPH + H+
tetrahydrobiopterin:NADP+ oxidoreductase (7,8-dihydrobiopterin-forming)
Swm_02761 K00560 thyA, TYMS R02101
dUMP + 5,10-Methylenetetrahydrofolate <=> Dihydrofolate + dTMP
5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
Antifolate resistanceHuman Diseases; Drug resistance: antineoplastic2 genes · 8 rxns
Swm_02760 K00287 DHFR, folA R00936
Tetrahydrofolate + NAD+ <=> Dihydrofolate + NADH + H+
5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
Swm_02760 K00287 DHFR, folA R00937
Tetrahydrofolate + 2 NAD+ <=> Folate + 2 NADH + 2 H+
5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
Swm_02760 K00287 DHFR, folA R00939
Tetrahydrofolate + NADP+ <=> Dihydrofolate + NADPH + H+
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
Swm_02760 K00287 DHFR, folA R00940
Tetrahydrofolate + 2 NADP+ <=> Folate + 2 NADPH + 2 H+
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
Swm_02760 K00287 DHFR, folA R02235
Dihydrofolate + NAD+ <=> Folate + NADH + H+
dihydrofolate:NAD+ oxidoreductase
Swm_02760 K00287 DHFR, folA R02236
Dihydrofolate + NADP+ <=> Folate + NADPH + H+
dihydrofolate:NADP+ oxidoreductase
Swm_02760 K00287 DHFR, folA R11765
Tetrahydrobiopterin + NADP+ <=> 7,8-Dihydrobiopterin + NADPH + H+
tetrahydrobiopterin:NADP+ oxidoreductase (7,8-dihydrobiopterin-forming)
Swm_02761 K00560 thyA, TYMS R02101
dUMP + 5,10-Methylenetetrahydrofolate <=> Dihydrofolate + dTMP
5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
Folate biosynthesisMetabolism; Metabolism of cofactors and vitamins1 genes · 7 rxns
Swm_02760 K00287 DHFR, folA R00936
Tetrahydrofolate + NAD+ <=> Dihydrofolate + NADH + H+
5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
Swm_02760 K00287 DHFR, folA R00937
Tetrahydrofolate + 2 NAD+ <=> Folate + 2 NADH + 2 H+
5,6,7,8-tetrahydrofolate:NAD+ oxidoreductase
Swm_02760 K00287 DHFR, folA R00939
Tetrahydrofolate + NADP+ <=> Dihydrofolate + NADPH + H+
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
Swm_02760 K00287 DHFR, folA R00940
Tetrahydrofolate + 2 NADP+ <=> Folate + 2 NADPH + 2 H+
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
Swm_02760 K00287 DHFR, folA R02235
Dihydrofolate + NAD+ <=> Folate + NADH + H+
dihydrofolate:NAD+ oxidoreductase
Swm_02760 K00287 DHFR, folA R02236
Dihydrofolate + NADP+ <=> Folate + NADPH + H+
dihydrofolate:NADP+ oxidoreductase
Swm_02760 K00287 DHFR, folA R11765
Tetrahydrobiopterin + NADP+ <=> 7,8-Dihydrobiopterin + NADPH + H+
tetrahydrobiopterin:NADP+ oxidoreductase (7,8-dihydrobiopterin-forming)
Pyrimidine metabolismMetabolism; Nucleotide metabolism1 genes · 1 rxns
Swm_02761 K00560 thyA, TYMS R02101
dUMP + 5,10-Methylenetetrahydrofolate <=> Dihydrofolate + dTMP
5,10-methylenetetrahydrofolate:dUMP C-methyltransferase

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 2 genes
Swm_02760 Swm_02761

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Swm_02758 phosphomethylpyrimidine synthase ThiC — — —
Swm_02759 SIR2 family protein — — —
Swm_02760 dihydrofolate reductase K00287 DHFR, folA 1.5.1.3 R00936,R00937,R00939,R00940,R02235,R02236,R11765
Swm_02761 thymidylate synthase K00560 thyA, TYMS 2.1.1.45 R02101
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