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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_CM128632.1:417,049–419,227

Syntrophomonas erecta DSM 16215 · 2 genes
2
genes
2
KO-annotated
5
reactions
6
pathways

Activity by pathway — click to expand; ranked by genes involved

Other carbon fixation pathwaysMetabolism; Energy metabolism2 genes · 5 rxns
Ser_00378 K00031 IDH1, IDH2, icd, IDP R00267
Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
isocitrate:NADP+ oxidoreductase (decarboxylating)
Ser_00378 K00031 IDH1, IDH2, icd, IDP R00268
Oxalosuccinate <=> 2-Oxoglutarate + CO2
oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
Ser_00378 K00031 IDH1, IDH2, icd, IDP R01899
Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
isocitrate:NADP+ oxidoreductase
Ser_00379 K00297 metF, MTHFR R01224
5-Methyltetrahydrofolate + NADP+ <=> 5,10-Methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate:NADP+ oxidoreductase
Ser_00379 K00297 metF, MTHFR R07168
5-Methyltetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate:NAD+ oxidoreductase
Citrate cycle (TCA cycle)Metabolism; Carbohydrate metabolism1 genes · 3 rxns
Ser_00378 K00031 IDH1, IDH2, icd, IDP R00267
Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
isocitrate:NADP+ oxidoreductase (decarboxylating)
Ser_00378 K00031 IDH1, IDH2, icd, IDP R00268
Oxalosuccinate <=> 2-Oxoglutarate + CO2
oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
Ser_00378 K00031 IDH1, IDH2, icd, IDP R01899
Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
isocitrate:NADP+ oxidoreductase
Glutathione metabolismMetabolism; Metabolism of other amino acids1 genes · 3 rxns
Ser_00378 K00031 IDH1, IDH2, icd, IDP R00267
Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
isocitrate:NADP+ oxidoreductase (decarboxylating)
Ser_00378 K00031 IDH1, IDH2, icd, IDP R00268
Oxalosuccinate <=> 2-Oxoglutarate + CO2
oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
Ser_00378 K00031 IDH1, IDH2, icd, IDP R01899
Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
isocitrate:NADP+ oxidoreductase
PeroxisomeCellular Processes; Transport and catabolism1 genes · 3 rxns
Ser_00378 K00031 IDH1, IDH2, icd, IDP R00267
Isocitrate + NADP+ <=> 2-Oxoglutarate + CO2 + NADPH + H+
isocitrate:NADP+ oxidoreductase (decarboxylating)
Ser_00378 K00031 IDH1, IDH2, icd, IDP R00268
Oxalosuccinate <=> 2-Oxoglutarate + CO2
oxalosuccinate carboxy-lyase (2-oxoglutarate-forming)
Ser_00378 K00031 IDH1, IDH2, icd, IDP R01899
Isocitrate + NADP+ <=> Oxalosuccinate + NADPH + H+
isocitrate:NADP+ oxidoreductase
One carbon pool by folateMetabolism; Metabolism of cofactors and vitamins1 genes · 2 rxns
Ser_00379 K00297 metF, MTHFR R01224
5-Methyltetrahydrofolate + NADP+ <=> 5,10-Methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate:NADP+ oxidoreductase
Ser_00379 K00297 metF, MTHFR R07168
5-Methyltetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate:NAD+ oxidoreductase
Antifolate resistanceHuman Diseases; Drug resistance: antineoplastic1 genes · 2 rxns
Ser_00379 K00297 metF, MTHFR R01224
5-Methyltetrahydrofolate + NADP+ <=> 5,10-Methylenetetrahydrofolate + NADPH + H+
5-methyltetrahydrofolate:NADP+ oxidoreductase
Ser_00379 K00297 metF, MTHFR R07168
5-Methyltetrahydrofolate + NAD+ <=> 5,10-Methylenetetrahydrofolate + NADH + H+
5-methyltetrahydrofolate:NAD+ oxidoreductase

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 2 genes
Ser_00378 Ser_00379
Microbial metabolism in diverse environments 2 genes
Ser_00378 Ser_00379
Carbon metabolism 2 genes
Ser_00378 Ser_00379
Biosynthesis of secondary metabolites 1 genes
Ser_00378
Map 01130 1 genes
Ser_00378
2-Oxocarboxylic acid metabolism 1 genes
Ser_00378
Biosynthesis of amino acids 1 genes
Ser_00378

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Ser_00378 NADP-dependent isocitrate dehydrogenase K00031 IDH1, IDH2, icd, IDP 1.1.1.42 R00267,R00268,R01899
Ser_00379 methylenetetrahydrofolate reductase [NAD(P)H] K00297 metF, MTHFR 1.5.1.20 R01224,R07168
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