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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_CM128632.1:1,416,703–1,418,673

Syntrophomonas erecta DSM 16215 · 2 genes
2
genes
2
KO-annotated
12
reactions
8
pathways

Activity by pathway — click to expand; ranked by genes involved

Valine, leucine and isoleucine degradationMetabolism; Amino acid metabolism1 genes · 8 rxns
Ser_01268 K11381 bkdA R07599
3-Methyl-2-oxobutanoic acid + Thiamin diphosphate <=> 2-Methyl-1-hydroxypropyl-ThPP + CO2
Ser_01268 K11381 bkdA R07600
2-Methyl-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + Thiamin diphosphate
Ser_01268 K11381 bkdA R07601
4-Methyl-2-oxopentanoate + Thiamin diphosphate <=> 3-Methyl-1-hydroxybutyl-ThPP + CO2
Ser_01268 K11381 bkdA R07602
3-Methyl-1-hydroxybutyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine + Thiamin diphosphate
Ser_01268 K11381 bkdA R07603
(S)-3-Methyl-2-oxopentanoic acid + Thiamin diphosphate <=> 2-Methyl-1-hydroxybutyl-ThPP + CO2
Ser_01268 K11381 bkdA R07604
2-Methyl-1-hydroxybutyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + Thiamin diphosphate
Ser_01268 K11381 bkdA R10996
2-Oxobutanoate + Thiamin diphosphate <=> 2-(alpha-Hydroxypropyl)thiamine diphosphate + CO2
Ser_01268 K11381 bkdA R10997
2-(alpha-Hydroxypropyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> Enzyme N6-(S-propyldihydrolipoyl)lysine + Thiamin diphosphate
Propanoate metabolismMetabolism; Carbohydrate metabolism1 genes · 8 rxns
Ser_01268 K11381 bkdA R07599
3-Methyl-2-oxobutanoic acid + Thiamin diphosphate <=> 2-Methyl-1-hydroxypropyl-ThPP + CO2
Ser_01268 K11381 bkdA R07600
2-Methyl-1-hydroxypropyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylpropanoyl)dihydrolipoyllysine + Thiamin diphosphate
Ser_01268 K11381 bkdA R07601
4-Methyl-2-oxopentanoate + Thiamin diphosphate <=> 3-Methyl-1-hydroxybutyl-ThPP + CO2
Ser_01268 K11381 bkdA R07602
3-Methyl-1-hydroxybutyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(3-methylbutanoyl)dihydrolipoyllysine + Thiamin diphosphate
Ser_01268 K11381 bkdA R07603
(S)-3-Methyl-2-oxopentanoic acid + Thiamin diphosphate <=> 2-Methyl-1-hydroxybutyl-ThPP + CO2
Ser_01268 K11381 bkdA R07604
2-Methyl-1-hydroxybutyl-ThPP + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase] S-(2-methylbutanoyl)dihydrolipoyllysine + Thiamin diphosphate
Ser_01268 K11381 bkdA R10996
2-Oxobutanoate + Thiamin diphosphate <=> 2-(alpha-Hydroxypropyl)thiamine diphosphate + CO2
Ser_01268 K11381 bkdA R10997
2-(alpha-Hydroxypropyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> Enzyme N6-(S-propyldihydrolipoyl)lysine + Thiamin diphosphate
Glycolysis / GluconeogenesisMetabolism; Carbohydrate metabolism1 genes · 4 rxns
Ser_01269 K00161 PDHA, pdhA R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Ser_01269 K00161 PDHA, pdhA R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Ser_01269 K00161 PDHA, pdhA R01699
Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
Ser_01269 K00161 PDHA, pdhA R03270
2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate
Citrate cycle (TCA cycle)Metabolism; Carbohydrate metabolism1 genes · 4 rxns
Ser_01269 K00161 PDHA, pdhA R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Ser_01269 K00161 PDHA, pdhA R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Ser_01269 K00161 PDHA, pdhA R01699
Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
Ser_01269 K00161 PDHA, pdhA R03270
2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate
Pyruvate metabolismMetabolism; Carbohydrate metabolism1 genes · 4 rxns
Ser_01269 K00161 PDHA, pdhA R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Ser_01269 K00161 PDHA, pdhA R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Ser_01269 K00161 PDHA, pdhA R01699
Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
Ser_01269 K00161 PDHA, pdhA R03270
2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate
HIF-1 signaling pathwayEnvironmental Information Processing; Signal transduction1 genes · 4 rxns
Ser_01269 K00161 PDHA, pdhA R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Ser_01269 K00161 PDHA, pdhA R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Ser_01269 K00161 PDHA, pdhA R01699
Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
Ser_01269 K00161 PDHA, pdhA R03270
2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate
Glucagon signaling pathwayOrganismal Systems; Endocrine system1 genes · 4 rxns
Ser_01269 K00161 PDHA, pdhA R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Ser_01269 K00161 PDHA, pdhA R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Ser_01269 K00161 PDHA, pdhA R01699
Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
Ser_01269 K00161 PDHA, pdhA R03270
2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate
Central carbon metabolism in cancerHuman Diseases; Cancer: overview1 genes · 4 rxns
Ser_01269 K00161 PDHA, pdhA R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Ser_01269 K00161 PDHA, pdhA R00209
Pyruvate + CoA + NAD+ <=> Acetyl-CoA + CO2 + NADH + H+
pyruvate:NAD+ 2-oxidoreductase (CoA-acetylating); pyruvate dehydrogenase complex
Ser_01269 K00161 PDHA, pdhA R01699
Pyruvate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2
pyruvate:[dihydrolipoyllysine-residue acetyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)
Ser_01269 K00161 PDHA, pdhA R03270
2-(alpha-Hydroxyethyl)thiamine diphosphate + Enzyme N6-(lipoyl)lysine <=> [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + Thiamin diphosphate

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 2 genes
Ser_01268 Ser_01269
Biosynthesis of secondary metabolites 2 genes
Ser_01268 Ser_01269
Map 01130 2 genes
Ser_01268 Ser_01269
Microbial metabolism in diverse environments 1 genes
Ser_01269
Carbon metabolism 1 genes
Ser_01269

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Ser_01268 alpha-ketoacid dehydrogenase subunit beta K11381 bkdA; K21417 acoB 1.2.4.4 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997
Ser_01269 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha K00161 PDHA, pdhA; K21416 acoA 1.2.4.1 R00014,R00209,R01699,R03270
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