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◀ domain architecture  ·  operons  ·  ❔ guide

Operon NZ_CM128632.1:2,624,892–2,628,837

Syntrophomonas erecta DSM 16215 · 3 genes
3
genes
3
KO-annotated
10
reactions
4
pathways

Activity by pathway — click to expand; ranked by genes involved

Valine, leucine and isoleucine biosynthesisMetabolism; Amino acid metabolism3 genes · 17 rxns
Ser_02417 K01687 ilvD R01209
2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O
2,3-dihydroxy-3-methylbutanoate hydro-lyase
Ser_02417 K01687 ilvD R04441
(R)-2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O
(R)-2,3-dihydroxy-3-methylbutanoate hydro-lyase
Ser_02417 K01687 ilvD R05070
(R)-2,3-Dihydroxy-3-methylpentanoate <=> (S)-3-Methyl-2-oxopentanoic acid + H2O
(R)-2,3-dihydroxy-3-methylpentanoate hydro-lyase
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Pantothenate and CoA biosynthesisMetabolism; Metabolism of cofactors and vitamins3 genes · 17 rxns
Ser_02417 K01687 ilvD R01209
2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O
2,3-dihydroxy-3-methylbutanoate hydro-lyase
Ser_02417 K01687 ilvD R04441
(R)-2,3-Dihydroxy-3-methylbutanoate <=> 3-Methyl-2-oxobutanoic acid + H2O
(R)-2,3-dihydroxy-3-methylbutanoate hydro-lyase
Ser_02417 K01687 ilvD R05070
(R)-2,3-Dihydroxy-3-methylpentanoate <=> (S)-3-Methyl-2-oxopentanoic acid + H2O
(R)-2,3-dihydroxy-3-methylpentanoate hydro-lyase
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Butanoate metabolismMetabolism; Carbohydrate metabolism2 genes · 14 rxns
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
C5-Branched dibasic acid metabolismMetabolism; Carbohydrate metabolism2 genes · 14 rxns
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Ser_02418 K01652 E2.2.1.6L, ilvB, ilvG, ilvI R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R00006
2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); 2-acetolactate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R00014
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R00226
(S)-2-Acetolactate + CO2 <=> 2 Pyruvate
pyruvate:pyruvate acetaldehydetransferase (decarboxylating); (S)-2-acetolactate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R03050
2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
2-acetolactate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R04672
(S)-2-Acetolactate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + Pyruvate
(S)-2-acetolactate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R04673
2-Oxobutanoate + 2-(alpha-Hydroxyethyl)thiamine diphosphate <=> (S)-2-Aceto-2-hydroxybutanoate + Thiamin diphosphate
(S)-2-aceto-2-hydroxybutanoate pyruvate-lyase (carboxylating)
Ser_02419 K01653 E2.2.1.6S, ilvH, ilvN R08648
Pyruvate + 2-Oxobutanoate <=> (S)-2-Aceto-2-hydroxybutanoate + CO2
pyruvate:2-oxobutanoate acetaldehydetransferase (decarboxylating)

Overview / global maps (every metabolic gene maps here)

Metabolic pathways 3 genes
Ser_02417 Ser_02418 Ser_02419
Biosynthesis of secondary metabolites 3 genes
Ser_02417 Ser_02418 Ser_02419
Map 01130 3 genes
Ser_02417 Ser_02418 Ser_02419
2-Oxocarboxylic acid metabolism 3 genes
Ser_02417 Ser_02418 Ser_02419
Biosynthesis of amino acids 3 genes
Ser_02417 Ser_02418 Ser_02419

Reaction network — compounds linked by the reactions these genes catalyse

drag nodes · click an edge for the reaction

Genes

LocusProductKOECReactions
Ser_02417 dihydroxy-acid dehydratase K01687 ilvD 4.2.1.9 R01209,R04441,R05070
Ser_02418 biosynthetic-type acetolactate synthase large subunit K01652 E2.2.1.6L, ilvB, ilvG, ilvI 2.2.1.6 R00006,R00014,R00226,R03050,R04672,R04673,R08648
Ser_02419 acetolactate synthase small subunit K01653 E2.2.1.6S, ilvH, ilvN 2.2.1.6 R00006,R00014,R00226,R03050,R04672,R04673,R08648
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